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- W2318713023 abstract "Cerebrospinal fluid (CSF) levels of soluble amyloid precursor protein (sAPP) and its α-secreted form (α-sAPP) were investigated as a means to distinguish between individuals with mild cognitive impairment (MCI) and Alzheimer-type dementia (DAT) and those with major depressive episode (MDE) showing secondary memory deficits.Twenty-seven patients with MCI, 32 with probable DAT, and 24 with MDE attending a memory clinic were studied. Cerebrospinal fluid levels of sAPP/amyloid precursor-like protein 2 (APLP2) and α-sAPP were detected by Western blotting.Patients with MDE had the highest CSF levels of total sAPP/APLP2 as compared with MCI and DAT patients (p < .001); sAPP/APLP2 levels were higher in MCI than in DAT subjects. Whereas α-sAPP levels did not differ between the MCI and DAT groups, median levels of this peptide were significantly lower in MCI and DAT versus MDE patients.Soluble amyloid precursor protein/APLP2 and α-sAPP concentrations in CSF can differentiate between DAT and MCI versus MDE, facilitating early ameliorative interventions and appropriate treatment regimens." @default.
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- W2318713023 date "2004-07-01" @default.
- W2318713023 modified "2023-09-27" @default.
- W2318713023 title "O4-04-07 Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP-family members" @default.
- W2318713023 doi "https://doi.org/10.1016/s0197-4580(04)80278-1" @default.
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