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- W2318721889 abstract "An 81-year-old man presented with a 8-week history of gradual onset of severe bilateral leg weakness followed by bilateral lower leg pain. MRI showed a diffusely contrast-enhancing intradural tumour approximately measuring 25 mm, situated just below the second lumbar vertebra, completely filling the vertebral canal. The radiological impression was ‘a filum ependymoma’. Intraoperatively a soft gray intradural-extramedullary vascular mass, adherent to and encased by the nerve roots of cauda equina, was identified. Light microscopy showed a small round blue cell tumour with histochemical, immunohistochemical and electron microscopic features characteristic of a Ewing’s sarcoma/primitive neuroectodermal tumour (ES/PNET). Molecular studies by reverse-transcriptase polymerase chain reaction (RT-PCR) showed t(11;22) involving EWS-FLI1 genes. The patient was reviewed by the oncology team and he underwent spinal irradiation. Intraspinal extraosseous ES/ PNETs are extremely rare. Less than 50 cases are reported to date, of which the oldest age reported in the English literature is 58 years. 1,2 Here, we report a case of intra-spinal extraosseous ES/PNET in an 81-year-old man. This case report highlights that the diagnosis of ES/ PNET needs to be considered in the differential diagnoses of a small round blue cell tumour in all age groups." @default.
- W2318721889 created "2016-06-24" @default.
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- W2318721889 date "2011-01-01" @default.
- W2318721889 modified "2023-09-25" @default.
- W2318721889 title "20. Intradural extraosseous ewing’s sarcoma/primitive neuroectodermal tumour in an octogenarian" @default.
- W2318721889 cites W2031605248 @default.
- W2318721889 cites W2050304819 @default.
- W2318721889 doi "https://doi.org/10.1016/s0031-3025(16)33308-6" @default.
- W2318721889 hasPublicationYear "2011" @default.
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