Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318739939> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2318739939 endingPage "S246" @default.
- W2318739939 startingPage "S246" @default.
- W2318739939 abstract "Agomelatine is a new antidepressant with an innovative pharmacological profile. It is a potent melatonergic agonist (MT1 and MT2) and also has 5-HT2c antagonist properties. Agometatine's efficacy in treating major depressive disorder (MDD) was first described in a placebo-controlled, dose-ranging study with paroxetine as a validator. In a recent placebo-controlled study, 212 MDD patients were randomly assigned double-blind to receive placebo or agomelatine 25 and 50 mg/day. There was a significant advantage for agomelatine after 6 weeks according to scores on the Hamilton Depression Rating Scale (HAM-D) (P = 0.026) and the Clinical Global Impression Severity (P = 0.017), with an improved response rate (P = 0.03). Robust evidence of agomelatine's efficacy in severe depression comes from analysis of a patient subgroup with baseline HAM-D scores >25. Analysis of pooled data from three different trials confirmed this observation and suggested that the agomelatine-placebo difference tends to increase with the severity of depression. Results suggest favorable tolerabitity of agomelatine compared with a serotonin and noradrenaline reuptake inhibitor, and agomelatine is associated with less sexual side effects that are troublesome with some antidepressants. As predicted from its pharmacological profile, agomelatine improves sleep quality without associated daytime drowsiness. Agomelatine was also shown not to induce a discontinuation syndrome. Agomelatine may fill the gap in the current therapeutic armamentarium by combining efficacy with a favorable tolerability profile and additional clinical benefits." @default.
- W2318739939 created "2016-06-24" @default.
- W2318739939 creator A5001240923 @default.
- W2318739939 creator A5003351140 @default.
- W2318739939 creator A5038507730 @default.
- W2318739939 creator A5068321695 @default.
- W2318739939 creator A5079336785 @default.
- W2318739939 creator A5081868995 @default.
- W2318739939 creator A5084147853 @default.
- W2318739939 date "2013-10-01" @default.
- W2318739939 modified "2023-10-16" @default.
- W2318739939 title "P.1.h.006 Anti-allodynic effects of agomelatine combined with gabapentin in neuropathic rats with infraorbital nerve constriction" @default.
- W2318739939 doi "https://doi.org/10.1016/s0924-977x(13)70382-1" @default.
- W2318739939 hasPublicationYear "2013" @default.
- W2318739939 type Work @default.
- W2318739939 sameAs 2318739939 @default.
- W2318739939 citedByCount "0" @default.
- W2318739939 crossrefType "journal-article" @default.
- W2318739939 hasAuthorship W2318739939A5001240923 @default.
- W2318739939 hasAuthorship W2318739939A5003351140 @default.
- W2318739939 hasAuthorship W2318739939A5038507730 @default.
- W2318739939 hasAuthorship W2318739939A5068321695 @default.
- W2318739939 hasAuthorship W2318739939A5079336785 @default.
- W2318739939 hasAuthorship W2318739939A5081868995 @default.
- W2318739939 hasAuthorship W2318739939A5084147853 @default.
- W2318739939 hasConcept C126322002 @default.
- W2318739939 hasConcept C142724271 @default.
- W2318739939 hasConcept C197934379 @default.
- W2318739939 hasConcept C204787440 @default.
- W2318739939 hasConcept C27081682 @default.
- W2318739939 hasConcept C2776000289 @default.
- W2318739939 hasConcept C2776608144 @default.
- W2318739939 hasConcept C2777107010 @default.
- W2318739939 hasConcept C2778375690 @default.
- W2318739939 hasConcept C2779144063 @default.
- W2318739939 hasConcept C2779177272 @default.
- W2318739939 hasConcept C2780051608 @default.
- W2318739939 hasConcept C2780798758 @default.
- W2318739939 hasConcept C2781161787 @default.
- W2318739939 hasConcept C42219234 @default.
- W2318739939 hasConcept C71924100 @default.
- W2318739939 hasConcept C98274493 @default.
- W2318739939 hasConceptScore W2318739939C126322002 @default.
- W2318739939 hasConceptScore W2318739939C142724271 @default.
- W2318739939 hasConceptScore W2318739939C197934379 @default.
- W2318739939 hasConceptScore W2318739939C204787440 @default.
- W2318739939 hasConceptScore W2318739939C27081682 @default.
- W2318739939 hasConceptScore W2318739939C2776000289 @default.
- W2318739939 hasConceptScore W2318739939C2776608144 @default.
- W2318739939 hasConceptScore W2318739939C2777107010 @default.
- W2318739939 hasConceptScore W2318739939C2778375690 @default.
- W2318739939 hasConceptScore W2318739939C2779144063 @default.
- W2318739939 hasConceptScore W2318739939C2779177272 @default.
- W2318739939 hasConceptScore W2318739939C2780051608 @default.
- W2318739939 hasConceptScore W2318739939C2780798758 @default.
- W2318739939 hasConceptScore W2318739939C2781161787 @default.
- W2318739939 hasConceptScore W2318739939C42219234 @default.
- W2318739939 hasConceptScore W2318739939C71924100 @default.
- W2318739939 hasConceptScore W2318739939C98274493 @default.
- W2318739939 hasLocation W23187399391 @default.
- W2318739939 hasOpenAccess W2318739939 @default.
- W2318739939 hasPrimaryLocation W23187399391 @default.
- W2318739939 hasRelatedWork W2023091818 @default.
- W2318739939 hasRelatedWork W2035840923 @default.
- W2318739939 hasRelatedWork W2068123007 @default.
- W2318739939 hasRelatedWork W2120729007 @default.
- W2318739939 hasRelatedWork W2146334349 @default.
- W2318739939 hasRelatedWork W2147244904 @default.
- W2318739939 hasRelatedWork W2185276659 @default.
- W2318739939 hasRelatedWork W2322520437 @default.
- W2318739939 hasRelatedWork W2414702536 @default.
- W2318739939 hasRelatedWork W2785338909 @default.
- W2318739939 hasVolume "23" @default.
- W2318739939 isParatext "false" @default.
- W2318739939 isRetracted "false" @default.
- W2318739939 magId "2318739939" @default.
- W2318739939 workType "article" @default.