FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318753073> ?p ?o ?g. }

• W2318753073 endingPage "A1" @default.
• W2318753073 startingPage "A1.1" @default.
• W2318753073 abstract "<h3>Objective</h3> Obesity is a traditional cardiovascular risk factor that affects one third of rheumatoid arthritis (RA) patients. Presently, the importance of obesity in RA activity remains unclear. This study aims to determine the influence of obesity on treatment response to biologic therapy evaluated by DAS28 at six months, in patients with RA, regardless of the targeted cytokine or cell, by analyzing a cohort of patients treated with anti-IL-6, TNFinhibitors (TNFi) or anti-CD20 therapies. <h3>Methods</h3> We conducted a retrospective longitudinal cohort study using the Rheumatic Diseases Portuguese Register (Reuma.pt). RA patients refractory to DMARD therapy, with at least 6 months of follow up after starting their first biologic therapy, with available data on weight and height at baseline were included. A DMARD naïve patients group was used as control Information was obtained on patient demographics, education, body mass index (BMI), present smoking status, disease duration, therapy, baseline disease activity score in 28 joints (DAS28), erosive disease, rheumatoid factor and anti-citrullinated protein antibodies, health assessment questionnaire (HAQ), type of biologic therapy (TNFi vs non-TNFi). BMI was categorised in two classes: non-obese (BMI <30) and obese (BMI > = 30 Kg/m2). Multivariate analysis was performed in order to evaluate the association between obesity and DAS 28 at 6 month and remission state (DAS28 <2.6). <h3>Results</h3> 317 patients treated for the first time with a biologic agent were included in this study. 23% were obese. We found a significant association between obesity and DAS28 at 6 months (β = 0.412 (0.045–0.779); p = 0.028). Other factors also showed a significant association namely baseline DAS28 (β = 0.514 (0.393–0.636); p < 0.001) and the use of a TNFi (β = 1.22 (0.787–1.653; p < 0.001). Considering disease remission the analysis did not show a significant association between obesity and DAS28 remission at 6 months for all biologic agents as a group (OR = 0.391 (0.132–1.161; p = 0.091). Baseline DAS28 (OR = 0.384 (0.264–0.597); p < 0.001) and the use of TNFi as a biologic therapy did show a significant association with achieving remission in these patients (OR = 0.037 (0.012–0.111); p < 0.001). In the 35 DMARD naïve patients evaluated we also found a significantly association of obesity and DAS28 at 6 months (β = 1.048 (0.227–1.829); p-value = 0.009) but not with remission (OR = 0.24 (0.006–1.938); p = 0.24). <h3>Conclusion</h3> Obesity predicts worse treatment response in rheumatoid arthritis. These results suggest that obese RA patients should be encouraged to reduce weight in order to improve disease control." @default.
• W2318753073 created "2016-06-24" @default.
• W2318753073 creator A5003223131 @default.
• W2318753073 creator A5009470103 @default.
• W2318753073 creator A5043747371 @default.
• W2318753073 creator A5048248640 @default.
• W2318753073 creator A5052477628 @default.
• W2318753073 creator A5067417557 @default.
• W2318753073 creator A5072808982 @default.
• W2318753073 creator A5083137734 @default.
• W2318753073 date "2014-01-31" @default.
• W2318753073 modified "2023-09-27" @default.
• W2318753073 title "A1.1 Obesity is a risk factor for worse treatment response in rheumatoid arthritis patients- results from reuma.pt" @default.
• W2318753073 doi "https://doi.org/10.1136/annrheumdis-2013-205124.1" @default.
• W2318753073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24489135" @default.
• W2318753073 hasPublicationYear "2014" @default.
• W2318753073 type Work @default.
• W2318753073 sameAs 2318753073 @default.
• W2318753073 citedByCount "10" @default.
• W2318753073 countsByYear W23187530732014 @default.
• W2318753073 countsByYear W23187530732015 @default.
• W2318753073 countsByYear W23187530732016 @default.
• W2318753073 countsByYear W23187530732018 @default.
• W2318753073 countsByYear W23187530732020 @default.
• W2318753073 countsByYear W23187530732022 @default.
• W2318753073 countsByYear W23187530732023 @default.
• W2318753073 crossrefType "journal-article" @default.
• W2318753073 hasAuthorship W2318753073A5003223131 @default.
• W2318753073 hasAuthorship W2318753073A5009470103 @default.
• W2318753073 hasAuthorship W2318753073A5043747371 @default.
• W2318753073 hasAuthorship W2318753073A5048248640 @default.
• W2318753073 hasAuthorship W2318753073A5052477628 @default.
• W2318753073 hasAuthorship W2318753073A5067417557 @default.
• W2318753073 hasAuthorship W2318753073A5072808982 @default.
• W2318753073 hasAuthorship W2318753073A5083137734 @default.
• W2318753073 hasConcept C126322002 @default.
• W2318753073 hasConcept C167135981 @default.
• W2318753073 hasConcept C1862650 @default.
• W2318753073 hasConcept C198451711 @default.
• W2318753073 hasConcept C2776232647 @default.
• W2318753073 hasConcept C2777575956 @default.
• W2318753073 hasConcept C2780221984 @default.
• W2318753073 hasConcept C50440223 @default.
• W2318753073 hasConcept C511355011 @default.
• W2318753073 hasConcept C71924100 @default.
• W2318753073 hasConcept C72563966 @default.
• W2318753073 hasConceptScore W2318753073C126322002 @default.
• W2318753073 hasConceptScore W2318753073C167135981 @default.
• W2318753073 hasConceptScore W2318753073C1862650 @default.
• W2318753073 hasConceptScore W2318753073C198451711 @default.
• W2318753073 hasConceptScore W2318753073C2776232647 @default.
• W2318753073 hasConceptScore W2318753073C2777575956 @default.
• W2318753073 hasConceptScore W2318753073C2780221984 @default.
• W2318753073 hasConceptScore W2318753073C50440223 @default.
• W2318753073 hasConceptScore W2318753073C511355011 @default.
• W2318753073 hasConceptScore W2318753073C71924100 @default.
• W2318753073 hasConceptScore W2318753073C72563966 @default.
• W2318753073 hasIssue "Suppl 1" @default.
• W2318753073 hasLocation W23187530731 @default.
• W2318753073 hasLocation W23187530732 @default.
• W2318753073 hasOpenAccess W2318753073 @default.
• W2318753073 hasPrimaryLocation W23187530731 @default.
• W2318753073 hasRelatedWork W1978435955 @default.
• W2318753073 hasRelatedWork W1999301958 @default.
• W2318753073 hasRelatedWork W2020968997 @default.
• W2318753073 hasRelatedWork W2023721760 @default.
• W2318753073 hasRelatedWork W2040203974 @default.
• W2318753073 hasRelatedWork W2155117280 @default.
• W2318753073 hasRelatedWork W2332108695 @default.
• W2318753073 hasRelatedWork W2412341873 @default.
• W2318753073 hasRelatedWork W2912447547 @default.
• W2318753073 hasRelatedWork W3088288988 @default.
• W2318753073 hasVolume "73" @default.
• W2318753073 isParatext "false" @default.
• W2318753073 isRetracted "false" @default.
• W2318753073 magId "2318753073" @default.
• W2318753073 workType "article" @default.