Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318774009> ?p ?o ?g. }
- W2318774009 abstract "Glutamate (GLU)-induced excitotoxicity is considered to be a frequent cause of cell degeneration in basal ganglia disorders; it is normally prevented by uptake of GLU by astrocytes. We recently found that transient perfusion of GLU in the striatum induces persistent accumulation of GLU in striatal astrocytes that could be from the initial administration or caused by the slow release from neurons or astrocytes in response to it. Endogenous production of GLU, that is, self-induced GLU accumulation (SIGA), may occur under physiological and pathological conditions. Here we studied the possible induction of SIGA after injury induced by perfusion of GLU receptor agonists into the striatum of rats. The agonists induced local degeneration in neurons and myelinated axons and microgliosis and astrocytosis; there was also gliosis and remote degeneration of neurons in the ventral-posterior complex of the thalamus that project to the cerebral cortex across the striatum. Reactive astrocytes showed persistent GLU accumulation in the striatum (local SIGA) and thalamus (remote SIGA) that persisted for at least 6 weeks after the injury. Thus, SIGA can be induced by neuronal degeneration retrogradely triggered from a remote brain region after excessive release of endogenous GLU from astrocytes. This may be an additional factor to be considered in basal ganglia disorders with glutamatergic excitotoxicity." @default.
- W2318774009 created "2016-06-24" @default.
- W2318774009 creator A5006570510 @default.
- W2318774009 creator A5017043888 @default.
- W2318774009 creator A5019988170 @default.
- W2318774009 creator A5027611272 @default.
- W2318774009 creator A5049760236 @default.
- W2318774009 date "2013-04-01" @default.
- W2318774009 modified "2023-10-06" @default.
- W2318774009 title "Striatal Glutamate Degenerates Thalamic Neurons" @default.
- W2318774009 cites W1484832749 @default.
- W2318774009 cites W1629086159 @default.
- W2318774009 cites W1947356649 @default.
- W2318774009 cites W1966335038 @default.
- W2318774009 cites W1969619562 @default.
- W2318774009 cites W1971668430 @default.
- W2318774009 cites W1971967768 @default.
- W2318774009 cites W1975300055 @default.
- W2318774009 cites W1976123847 @default.
- W2318774009 cites W1977489226 @default.
- W2318774009 cites W1979945816 @default.
- W2318774009 cites W1981128350 @default.
- W2318774009 cites W1988622967 @default.
- W2318774009 cites W1990195639 @default.
- W2318774009 cites W1992525412 @default.
- W2318774009 cites W1994638214 @default.
- W2318774009 cites W2007568201 @default.
- W2318774009 cites W2008352579 @default.
- W2318774009 cites W2010694374 @default.
- W2318774009 cites W2011123334 @default.
- W2318774009 cites W2026688064 @default.
- W2318774009 cites W2026982903 @default.
- W2318774009 cites W2030884439 @default.
- W2318774009 cites W2032269048 @default.
- W2318774009 cites W2036683529 @default.
- W2318774009 cites W2041591122 @default.
- W2318774009 cites W2050744136 @default.
- W2318774009 cites W2052064431 @default.
- W2318774009 cites W2058107876 @default.
- W2318774009 cites W2063140713 @default.
- W2318774009 cites W2065663423 @default.
- W2318774009 cites W2071984286 @default.
- W2318774009 cites W2073607297 @default.
- W2318774009 cites W2074661552 @default.
- W2318774009 cites W2078586203 @default.
- W2318774009 cites W2084295563 @default.
- W2318774009 cites W2085141229 @default.
- W2318774009 cites W2085301440 @default.
- W2318774009 cites W2091155140 @default.
- W2318774009 cites W2094735076 @default.
- W2318774009 cites W2097423163 @default.
- W2318774009 cites W2102532330 @default.
- W2318774009 cites W2102560654 @default.
- W2318774009 cites W2111264921 @default.
- W2318774009 cites W2111343607 @default.
- W2318774009 cites W2112319251 @default.
- W2318774009 cites W2120412340 @default.
- W2318774009 cites W2120453252 @default.
- W2318774009 cites W2128744963 @default.
- W2318774009 cites W2134230622 @default.
- W2318774009 cites W2134733089 @default.
- W2318774009 cites W2143959688 @default.
- W2318774009 cites W2150929583 @default.
- W2318774009 cites W2155448528 @default.
- W2318774009 cites W2160282214 @default.
- W2318774009 cites W4210979710 @default.
- W2318774009 cites W4210981518 @default.
- W2318774009 doi "https://doi.org/10.1097/nen.0b013e31828a80ee" @default.
- W2318774009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23481706" @default.
- W2318774009 hasPublicationYear "2013" @default.
- W2318774009 type Work @default.
- W2318774009 sameAs 2318774009 @default.
- W2318774009 citedByCount "8" @default.
- W2318774009 countsByYear W23187740092014 @default.
- W2318774009 countsByYear W23187740092015 @default.
- W2318774009 countsByYear W23187740092016 @default.
- W2318774009 countsByYear W23187740092017 @default.
- W2318774009 countsByYear W23187740092019 @default.
- W2318774009 countsByYear W23187740092021 @default.
- W2318774009 crossrefType "journal-article" @default.
- W2318774009 hasAuthorship W2318774009A5006570510 @default.
- W2318774009 hasAuthorship W2318774009A5017043888 @default.
- W2318774009 hasAuthorship W2318774009A5019988170 @default.
- W2318774009 hasAuthorship W2318774009A5027611272 @default.
- W2318774009 hasAuthorship W2318774009A5049760236 @default.
- W2318774009 hasBestOaLocation W23187740091 @default.
- W2318774009 hasConcept C169760540 @default.
- W2318774009 hasConcept C170493617 @default.
- W2318774009 hasConcept C2777542381 @default.
- W2318774009 hasConcept C2777682930 @default.
- W2318774009 hasConcept C2778187257 @default.
- W2318774009 hasConcept C2779246727 @default.
- W2318774009 hasConcept C2780062018 @default.
- W2318774009 hasConcept C2780648746 @default.
- W2318774009 hasConcept C2781012912 @default.
- W2318774009 hasConcept C2781041448 @default.
- W2318774009 hasConcept C2908656565 @default.
- W2318774009 hasConcept C513476851 @default.
- W2318774009 hasConcept C529278444 @default.
- W2318774009 hasConcept C55493867 @default.