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- W2318774857 abstract "Hypercalcemia occurs in most granulomatous disorders. High serum calcium levels are seen in about 10% of patients with sarcoidosis; hypercalciuria is about three times more frequent. Tuberculosis, fungal granulomas, berylliosis, and lymphomas are other conditions that are associated with disorders of calcium metabolism. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH2)D3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroquine, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy." @default.
- W2318774857 created "2016-06-24" @default.
- W2318774857 creator A5079994412 @default.
- W2318774857 date "2000-09-01" @default.
- W2318774857 modified "2023-10-01" @default.
- W2318774857 title "Hypercalcemia in granulomatous disorders: a clinical review" @default.
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- W2318774857 doi "https://doi.org/10.1097/00063198-200009000-00010" @default.
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