Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318777002> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2318777002 endingPage "101" @default.
- W2318777002 startingPage "1097" @default.
- W2318777002 abstract "Three patients with karyotype XYY who had presented with deep vein thrombosis and leg ulcers (plus pulmonary embolism in two of them) were investigated for: (1) androgens (plasma testosterone measurement, testosterone oestradiol binding globulin (TeBG) assay, GnRH 50 micrograms test), and (2) haemostasis by fibrinolysis tests (euglobulin lysis time and area, antigenic plasminogen activator assay before and after 10 min venostasis). Full evaluation of haemostasis failed to demonstrate the presence of circulating anticoagulant or of antithrombin III, protein C and protein S deficiencies. One patient had neither hormonal nor fibrinolytic abnormality. The other two patients shared some clinical features with male hypogonadism (gynoid morphotype in both, hypotrophy of the testes in one, gynaecomastia in the other). They also had hormonal disorders (over-response to the GnRH test in one case, elevated TeGB in the other case) and abnormalities of fibrinolysis (poor response to venostasis, high baseline level of plasminogen activator). Response to venostasis became normal after 3 months of treatment with percutaneous dihydrosterone 125 mg per day in the two patients with initially poor response. The mechanism of venous pathology in XYY subjects is discussed. A genetic defect not involving the fibrinolysis system is possible since fibrinolysis was normal in one patient; however, abnormal fibrinolysis may have been responsible for the venous pathology in the other 2 patients. The role played by abnormalities of fibrinolysis in the pathogenesis of deep vein thrombosis and leg ulcers is recalled, and the possible implication of these abnormalities in patients with XYY karyotype is emphasized.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2318777002 created "2016-06-24" @default.
- W2318777002 creator A5018598346 @default.
- W2318777002 creator A5031863120 @default.
- W2318777002 creator A5038680086 @default.
- W2318777002 creator A5049248014 @default.
- W2318777002 creator A5055392111 @default.
- W2318777002 date "1987-01-01" @default.
- W2318777002 modified "2023-09-23" @default.
- W2318777002 title "[Post-phlebitic leg ulcers and XYY karyotype: fibrinolysis and androgenic function tests. Apropos of 3 cases]." @default.
- W2318777002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3434947" @default.
- W2318777002 hasPublicationYear "1987" @default.
- W2318777002 type Work @default.
- W2318777002 sameAs 2318777002 @default.
- W2318777002 citedByCount "1" @default.
- W2318777002 crossrefType "journal-article" @default.
- W2318777002 hasAuthorship W2318777002A5018598346 @default.
- W2318777002 hasAuthorship W2318777002A5031863120 @default.
- W2318777002 hasAuthorship W2318777002A5038680086 @default.
- W2318777002 hasAuthorship W2318777002A5049248014 @default.
- W2318777002 hasAuthorship W2318777002A5055392111 @default.
- W2318777002 hasConcept C126322002 @default.
- W2318777002 hasConcept C134018914 @default.
- W2318777002 hasConcept C142724271 @default.
- W2318777002 hasConcept C2776825266 @default.
- W2318777002 hasConcept C2779679481 @default.
- W2318777002 hasConcept C2780868729 @default.
- W2318777002 hasConcept C71924100 @default.
- W2318777002 hasConcept C90924648 @default.
- W2318777002 hasConceptScore W2318777002C126322002 @default.
- W2318777002 hasConceptScore W2318777002C134018914 @default.
- W2318777002 hasConceptScore W2318777002C142724271 @default.
- W2318777002 hasConceptScore W2318777002C2776825266 @default.
- W2318777002 hasConceptScore W2318777002C2779679481 @default.
- W2318777002 hasConceptScore W2318777002C2780868729 @default.
- W2318777002 hasConceptScore W2318777002C71924100 @default.
- W2318777002 hasConceptScore W2318777002C90924648 @default.
- W2318777002 hasIssue "9" @default.
- W2318777002 hasLocation W23187770021 @default.
- W2318777002 hasOpenAccess W2318777002 @default.
- W2318777002 hasPrimaryLocation W23187770021 @default.
- W2318777002 hasRelatedWork W1781372697 @default.
- W2318777002 hasRelatedWork W1987480297 @default.
- W2318777002 hasRelatedWork W2001757582 @default.
- W2318777002 hasRelatedWork W2004260519 @default.
- W2318777002 hasRelatedWork W2018316010 @default.
- W2318777002 hasRelatedWork W2021566081 @default.
- W2318777002 hasRelatedWork W2046372490 @default.
- W2318777002 hasRelatedWork W2054461356 @default.
- W2318777002 hasRelatedWork W2091211157 @default.
- W2318777002 hasRelatedWork W2151419087 @default.
- W2318777002 hasVolume "114" @default.
- W2318777002 isParatext "false" @default.
- W2318777002 isRetracted "false" @default.
- W2318777002 magId "2318777002" @default.
- W2318777002 workType "article" @default.