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- W2318789904 abstract "Background: In chronic Chagas disease (ChD), impairment of cardiac autonomic function bears prognostic implications. Phase-rectification of RR-interval series isolates the sympathetic, acceleration phase (AC) and parasympathetic, deceleration phase (DC) influences on cardiac autonomic modulation. Objective: This study investigated heart rate variability (HRV) as a function of RR-interval to assess autonomic function in healthy and ChD subjects. Methods: Control (n = 20) and ChD (n = 20) groups were studied. All underwent 60-min head-up tilt table test under ECG recording. Histogram of RR-interval series was calculated, with 100 ms class, ranging from 600–1100 ms. In each class, mean RR-intervals (MNN) and root-mean-squared difference (RMSNN) of consecutive normal RR-intervals that suited a particular class were calculated. Average of all RMSNN values in each class was analyzed as function of MNN, in the whole series (RMSNN T ), and in AC (RMSNN AC ) and DC (RMSNN DC ) phases. Slopes of linear regression lines were compared between groups using Student t-test. Correlation coefficients were tested before comparisons. RMSNN was log-transformed. (α < 0.05). Results: Correlation coefficient was significant in all regressions (p < 0.05). In the control group, RMSNN T , RMSNN AC , and RMSNN DC significantly increased linealy with MNN (p < 0.05). In ChD, only RMSNN AC showed significant increase as a function of MNN, whereas RMSNN T and RMSNN DC did not. Conclusion: HRV increases in proportion with the RR-interval in healthy subjects. This behavior is lost in ChD, particularly in the DC phase, indicating cardiac vagal incompetence." @default.
- W2318789904 created "2016-06-24" @default.
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- W2318789904 date "2014-01-01" @default.
- W2318789904 modified "2023-09-27" @default.
- W2318789904 title "Fundamento: Na doença de Chagas (DCh) crônica, a função autonômica cardíaca está frequentemente comprometida e traz implicações quanto ao prognóstico. A retificação de fase da série de intervalos RR isola as influências simpática (fase de aceleração - AC) e parassimpática (fase de desaceleração - DC) na modulação autonômica cardíaca. Objetivo: Este estudo investigou a variabilidade da frequência cardíaca (VRR) como função dos intervalos RR, para avaliar a" @default.
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