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- W2318789946 abstract "Siliphos-selenium-methionine-alpha lipoic acid (SSMAL) has been used to treat chronic hepatic diseases, although formal evaluation of this mixture with clinical trials is lacking. We conduct this pilot study to investigate the safety and effectiveness of SSMAL in patients with non-alcoholic fatty liver disease (NAFLD). Forty NAFLD patients were randomized into two groups. All patients received metformin 1500 mg q.a.d. added to nutritional and exercise advice. Twenty patients received selenium (15 mcg) – methionine (3 mg)-alpha lipoic acid (200 mg) group. After 24 weeks, basal versus final biochemical and image studies were compared. Patients from SSMAL group, had a decrease in steatosis graded by ultrasound 70% vs. 15% (p<0.001) and showed lower rates of liver enzymes than control group. Pro-inflammatory cytokines profile and the reduced antioxidant status noted in NAFLD patients showed improvement with this therapy. Adiponectin was significantly increased in both groups and it changed with active therapy. No serious adverse reactions were reported. This is the first study to systematically assess SSMAL in NAFLD patients. Treatment for 6 months may protect against worsening steatosis and improve the inflammatory profile. These findings warrant further investigation. (NTC01650181)" @default.
- W2318789946 created "2016-06-24" @default.
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- W2318789946 date "2014-01-01" @default.
- W2318789946 modified "2023-09-25" @default.
- W2318789946 title "Siliphos Selenium Methionine Alpha Lipoic Acid for Non Alcoholic Fatty Liver Disease: Results of a Pilot Study" @default.
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- W2318789946 doi "https://doi.org/10.4172/2161-1459.1000167" @default.
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