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- W2318808049 abstract "The first, asymmetric total syntheses of potent antimicrobial Psoracorylifol B (>1.3 g obtained, dr 10.5:1) with a 9.4% overall yield on a gram scale in 14 steps and ent-Psoracorylifol C with a 4.3% yield in 16 steps were achieved. The key features of our synthesis include (i) sequential, rarely explored Achmatowicz rearrangement/bicycloketalization to construct the 6,8-dioxabicyclo[3.2.1]octane core, and (ii) Cu-mediated SN2′ methylation or Johnson–Claisen rearrangement to stereoselectively install the all-carbon quaternary stereocenter. This concise, highly efficient, and scalable synthetic route may provide expedited and practical access to psoracorylifols and their analogues for further biological activity evaluation." @default.
- W2318808049 created "2016-06-24" @default.
- W2318808049 creator A5025184402 @default.
- W2318808049 creator A5040894587 @default.
- W2318808049 creator A5042455393 @default.
- W2318808049 creator A5046214153 @default.
- W2318808049 date "2014-05-12" @default.
- W2318808049 modified "2023-10-14" @default.
- W2318808049 title "Scalable Asymmetric Total Syntheses of (+)-Psoracorylifol B and (+)-<i>ent</i>-Psoracorylifol C" @default.
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- W2318808049 cites W1973417213 @default.
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- W2318808049 cites W1976878228 @default.
- W2318808049 cites W1981670174 @default.
- W2318808049 cites W1984944837 @default.
- W2318808049 cites W1993008721 @default.
- W2318808049 cites W1994238881 @default.
- W2318808049 cites W1996798433 @default.
- W2318808049 cites W2003564271 @default.
- W2318808049 cites W2005462498 @default.
- W2318808049 cites W2009132123 @default.
- W2318808049 cites W2022277187 @default.
- W2318808049 cites W2024619926 @default.
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- W2318808049 cites W2030026872 @default.
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- W2318808049 doi "https://doi.org/10.1021/ol501120m" @default.
- W2318808049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24819702" @default.
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