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- W2318868196 abstract "Ammonia metabolism in the human skin was studied by skin ammonia which was determined with Okuda’s method for direct quantitative colorimetry as well as column chromatography. The results are as follows. 1) The human skin of a whole leyer contained 3.3±1.3μg of ammonia per 100mg of the skin by wet weight. 2) The highest ammonia level was detarmined in the lower dermis portion. 3) Ammonia biosynthesis in the human skin was as potential as in the muscles, which amounted 2.7μg/100mg of the skin by wet weight after incubation for 90 minutes at 37°C. However a similar biosynthesis was not observed in the subcutaneous fat tissue. The skin ammonia was redeemed to be produced most preminently in the epidermis and the upperdermis. 4) The hnman skin ammonia was considered to be produced primarily from adenosine and a series of the nucleotides, i. e. ATP, ADP and AMP as well as amino acids. 5) Two principal biosynthetic pathways of the human skin ammonia are presumed to be one by which IMP and ammonia are produced through AMP deamination by AMP deaminase, and another, Inosine and ammonia produced through adenosine deamination by adenosine deaminase." @default.
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- W2318868196 date "1972-01-01" @default.
- W2318868196 modified "2023-09-24" @default.
- W2318868196 title "Studies on Ammonia Metabolism in Human Skin" @default.
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- W2318868196 doi "https://doi.org/10.2336/nishinihonhifu.34.309" @default.
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