Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318882471> ?p ?o ?g. }
- W2318882471 endingPage "2321" @default.
- W2318882471 startingPage "2312" @default.
- W2318882471 abstract "Epothilones are natural compounds isolated from a myxobacterium at the beginning of the 1990s, and showed a remarkable anti-neoplastic activity. They act through the same mechanism of action of paclitaxel, by stabilizing microtubules and inducing apoptosis. Although, their chemical structure, simpler than taxanes, makes them more suitable for derivatization. Their interesting pharmacokinetic and bioavailabilty profiles, and the activity against paclitaxel-resistant cell lines make them interesting therapeutic agents. Here a brief historical perspective of epothilones is presented, since their isolation, the identification of their mechanism of action and activity, to the recent clinical trials." @default.
- W2318882471 created "2016-06-24" @default.
- W2318882471 creator A5068867875 @default.
- W2318882471 date "2014-12-12" @default.
- W2318882471 modified "2023-10-16" @default.
- W2318882471 title "Epothilones: From Discovery to Clinical Trials" @default.
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