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- W2318893400 abstract "To evaluate the clinical significance of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). we analyzed plasma concentrations of MMP-1, 2, 3, 9 and TIMP-1, 2 in patients with breast cancer (patient group) using the enzyme immuno-assay technique. The average levels in 32 patients were compared with the levels of 50 healthy women (control group). The average levels of all MMPs were no higher in the patient group than in the control group. On the contrary, the average level of TIMP-1 was significantly lower in the patient group than in the control group. Thus, the total concentration of MMPs divided by the total concentration of TIMPs (MMPs/TIMPs ratio) was elevated in the patient group. Furthermore, the MMPs/TIMPs ratio correlated with the lymphatic permeation. These results suggest that the TIMP-1 and the MMPs/TIMPs ratio correlate with lymphatic permeation of breast cancer." @default.
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- W2318893400 date "1998-01-01" @default.
- W2318893400 modified "2023-09-25" @default.
- W2318893400 title "ANALYSES OF PLASMA METALLOPROTEINASES AND TISSUE INHIBITOR OF METALLOPROTEINASES IN PATIENTS WITH BREAST CANCER" @default.
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- W2318893400 doi "https://doi.org/10.3919/jjsa.59.6" @default.
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