FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318897461> ?p ?o ?g. }

• W2318897461 endingPage "ddw105" @default.
• W2318897461 startingPage "ddw105" @default.
• W2318897461 abstract "Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons resulting in a catastrophic loss of motor function. Current therapies are severely limited owing to a poor mechanistic understanding of the pathobiology. Mutations in a large number of genes have now been linked to ALS, including SOD1, TARDBP (TDP-43), FUS and C9orf72. Functional analyses of these genes and their pathogenic mutations have provided great insights into the underlying disease mechanisms. Defective axonal transport is hypothesized to be a key factor in the selective vulnerability of motor nerves due to their extraordinary length and evidence that ALS occurs as a distal axonopathy. Axonal transport is seen as an early pathogenic event that precedes cell loss and clinical symptoms and so represents an upstream mechanism for therapeutic targeting. Studies have begun to describe the impact of a few pathogenic mutations on axonal transport but a broad survey across a range of models and cargos is warranted. Here, we assessed the axonal transport of different cargos in multiple Drosophila models of ALS. We found that axonal transport defects are common across all models tested, although they often showed a differential effect between mitochondria and vesicle cargos. Motor deficits were also common across the models and generally worsened with age, though surprisingly there was not a clear correlation between the severity of axonal transport defects and motor ability. These results further support defects in axonal transport as a common factor in models of ALS that may contribute to the pathogenic process." @default.
• W2318897461 created "2016-06-24" @default.
• W2318897461 creator A5050783991 @default.
• W2318897461 creator A5068615498 @default.
• W2318897461 creator A5079996040 @default.
• W2318897461 creator A5088181905 @default.
• W2318897461 date "2016-04-07" @default.
• W2318897461 modified "2023-10-06" @default.
• W2318897461 title "Axonal transport defects are a common phenotype in<i>Drosophila</i>models of ALS" @default.
• W2318897461 cites W1137678651 @default.
• W2318897461 cites W131176016 @default.
• W2318897461 cites W1796096082 @default.
• W2318897461 cites W1797572428 @default.
• W2318897461 cites W1967443709 @default.
• W2318897461 cites W1967601924 @default.
• W2318897461 cites W1967851074 @default.
• W2318897461 cites W1968683040 @default.
• W2318897461 cites W1974961961 @default.
• W2318897461 cites W1980913885 @default.
• W2318897461 cites W1983335981 @default.
• W2318897461 cites W1985912952 @default.
• W2318897461 cites W2011396520 @default.
• W2318897461 cites W2013131112 @default.
• W2318897461 cites W2013488820 @default.
• W2318897461 cites W2020184434 @default.
• W2318897461 cites W2020815630 @default.
• W2318897461 cites W2030411520 @default.
• W2318897461 cites W2032719480 @default.
• W2318897461 cites W2038438413 @default.
• W2318897461 cites W2039073478 @default.
• W2318897461 cites W2040773899 @default.
• W2318897461 cites W2054542675 @default.
• W2318897461 cites W2060706160 @default.
• W2318897461 cites W2063996210 @default.
• W2318897461 cites W2067015275 @default.
• W2318897461 cites W2069171272 @default.
• W2318897461 cites W2073190029 @default.
• W2318897461 cites W2074795212 @default.
• W2318897461 cites W2075588816 @default.
• W2318897461 cites W2080964315 @default.
• W2318897461 cites W2088461570 @default.
• W2318897461 cites W2091145925 @default.
• W2318897461 cites W2092145129 @default.
• W2318897461 cites W2098718365 @default.
• W2318897461 cites W2101042581 @default.
• W2318897461 cites W2106526071 @default.
• W2318897461 cites W2111335223 @default.
• W2318897461 cites W2112538318 @default.
• W2318897461 cites W2112710669 @default.
• W2318897461 cites W2114872355 @default.
• W2318897461 cites W2115670698 @default.
• W2318897461 cites W2119679922 @default.
• W2318897461 cites W2126871157 @default.
• W2318897461 cites W2130062777 @default.
• W2318897461 cites W2133400638 @default.
• W2318897461 cites W2136949432 @default.
• W2318897461 cites W2137039075 @default.
• W2318897461 cites W2146627025 @default.
• W2318897461 cites W2149090315 @default.
• W2318897461 cites W2150090276 @default.
• W2318897461 cites W2150130630 @default.
• W2318897461 cites W2150523249 @default.
• W2318897461 cites W2150860983 @default.
• W2318897461 cites W2154417593 @default.
• W2318897461 cites W2154923417 @default.
• W2318897461 cites W2154945114 @default.
• W2318897461 cites W2162149714 @default.
• W2318897461 cites W2291344423 @default.
• W2318897461 doi "https://doi.org/10.1093/hmg/ddw105" @default.
• W2318897461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5181624" @default.
• W2318897461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27056981" @default.
• W2318897461 hasPublicationYear "2016" @default.
• W2318897461 type Work @default.
• W2318897461 sameAs 2318897461 @default.
• W2318897461 citedByCount "70" @default.
• W2318897461 countsByYear W23188974612016 @default.
• W2318897461 countsByYear W23188974612017 @default.
• W2318897461 countsByYear W23188974612018 @default.
• W2318897461 countsByYear W23188974612019 @default.
• W2318897461 countsByYear W23188974612020 @default.
• W2318897461 countsByYear W23188974612021 @default.
• W2318897461 countsByYear W23188974612022 @default.
• W2318897461 countsByYear W23188974612023 @default.
• W2318897461 crossrefType "journal-article" @default.
• W2318897461 hasAuthorship W2318897461A5050783991 @default.
• W2318897461 hasAuthorship W2318897461A5068615498 @default.
• W2318897461 hasAuthorship W2318897461A5079996040 @default.
• W2318897461 hasAuthorship W2318897461A5088181905 @default.
• W2318897461 hasBestOaLocation W23188974611 @default.
• W2318897461 hasConcept C104317684 @default.
• W2318897461 hasConcept C127716648 @default.
• W2318897461 hasConcept C142724271 @default.
• W2318897461 hasConcept C143065580 @default.
• W2318897461 hasConcept C166252455 @default.
• W2318897461 hasConcept C169760540 @default.
• W2318897461 hasConcept C180754005 @default.
• W2318897461 hasConcept C2777615887 @default.
• W2318897461 hasConcept C2777898937 @default.

• next