Matches in SemOpenAlex for { <https://semopenalex.org/work/W2318903071> ?p ?o ?g. }
- W2318903071 endingPage "3765" @default.
- W2318903071 startingPage "3757" @default.
- W2318903071 abstract "Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphatase 2A through the phosphatase Bα subunit. It was further shown that PP2A is required for performing the various E4orf4 functions. We report here that E4orf4 interacts with multiple isoforms of the PP2A-B′ subunit, as well as with Bα. We map the interaction sites of the B subunits on E4orf4 and show that they overlap but are not identical. We identify a dominant negative E4orf4 mutant, which disrupts the PP2A holoenzyme. We show that induction of apoptosis by E4orf4, which we previously reported to require the interaction with Bα, is not affected by the interaction with B′. Our results suggest that the interaction of E4orf4 with various PP2A subpopulations may mediate the different E4orf4 functions." @default.
- W2318903071 created "2016-06-24" @default.
- W2318903071 creator A5004998934 @default.
- W2318903071 creator A5070088242 @default.
- W2318903071 creator A5081935873 @default.
- W2318903071 date "2000-07-28" @default.
- W2318903071 modified "2023-09-27" @default.
- W2318903071 title "Adenovirus E4orf4 protein interacts with both Bα and B′ subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα" @default.
- W2318903071 cites W1551942931 @default.
- W2318903071 cites W1560526335 @default.
- W2318903071 cites W1642473590 @default.
- W2318903071 cites W1892570697 @default.
- W2318903071 cites W1924891182 @default.
- W2318903071 cites W1964739066 @default.
- W2318903071 cites W1965372133 @default.
- W2318903071 cites W1966412214 @default.
- W2318903071 cites W1968157723 @default.
- W2318903071 cites W1973158635 @default.
- W2318903071 cites W1980530230 @default.
- W2318903071 cites W1991471131 @default.
- W2318903071 cites W1992701498 @default.
- W2318903071 cites W2004530777 @default.
- W2318903071 cites W2005396278 @default.
- W2318903071 cites W2005426753 @default.
- W2318903071 cites W2006400218 @default.
- W2318903071 cites W2022734399 @default.
- W2318903071 cites W2026508325 @default.
- W2318903071 cites W2031146595 @default.
- W2318903071 cites W2041705004 @default.
- W2318903071 cites W2044296969 @default.
- W2318903071 cites W2052860581 @default.
- W2318903071 cites W2053718673 @default.
- W2318903071 cites W2055433327 @default.
- W2318903071 cites W2057221801 @default.
- W2318903071 cites W2062708599 @default.
- W2318903071 cites W2063123880 @default.
- W2318903071 cites W2064264293 @default.
- W2318903071 cites W2065231473 @default.
- W2318903071 cites W2071308259 @default.
- W2318903071 cites W2094900302 @default.
- W2318903071 cites W2098489231 @default.
- W2318903071 cites W2107199882 @default.
- W2318903071 cites W2126648733 @default.
- W2318903071 cites W2135476883 @default.
- W2318903071 cites W2137221055 @default.
- W2318903071 cites W2146377171 @default.
- W2318903071 cites W2150446853 @default.
- W2318903071 cites W2155611139 @default.
- W2318903071 cites W2162471952 @default.
- W2318903071 cites W217424672 @default.
- W2318903071 cites W2288796536 @default.
- W2318903071 cites W2325151665 @default.
- W2318903071 cites W4237606509 @default.
- W2318903071 doi "https://doi.org/10.1038/sj.onc.1203705" @default.
- W2318903071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10949930" @default.
- W2318903071 hasPublicationYear "2000" @default.
- W2318903071 type Work @default.
- W2318903071 sameAs 2318903071 @default.
- W2318903071 citedByCount "69" @default.
- W2318903071 countsByYear W23189030712012 @default.
- W2318903071 countsByYear W23189030712013 @default.
- W2318903071 countsByYear W23189030712014 @default.
- W2318903071 countsByYear W23189030712015 @default.
- W2318903071 countsByYear W23189030712016 @default.
- W2318903071 countsByYear W23189030712019 @default.
- W2318903071 crossrefType "journal-article" @default.
- W2318903071 hasAuthorship W2318903071A5004998934 @default.
- W2318903071 hasAuthorship W2318903071A5070088242 @default.
- W2318903071 hasAuthorship W2318903071A5081935873 @default.
- W2318903071 hasBestOaLocation W23189030711 @default.
- W2318903071 hasConcept C104292427 @default.
- W2318903071 hasConcept C104317684 @default.
- W2318903071 hasConcept C11960822 @default.
- W2318903071 hasConcept C143065580 @default.
- W2318903071 hasConcept C153911025 @default.
- W2318903071 hasConcept C178666793 @default.
- W2318903071 hasConcept C190283241 @default.
- W2318903071 hasConcept C389152 @default.
- W2318903071 hasConcept C53345823 @default.
- W2318903071 hasConcept C54355233 @default.
- W2318903071 hasConcept C54458228 @default.
- W2318903071 hasConcept C62478195 @default.
- W2318903071 hasConcept C67705224 @default.
- W2318903071 hasConcept C71829478 @default.
- W2318903071 hasConcept C81885089 @default.
- W2318903071 hasConcept C86803240 @default.
- W2318903071 hasConcept C95444343 @default.
- W2318903071 hasConceptScore W2318903071C104292427 @default.
- W2318903071 hasConceptScore W2318903071C104317684 @default.
- W2318903071 hasConceptScore W2318903071C11960822 @default.
- W2318903071 hasConceptScore W2318903071C143065580 @default.
- W2318903071 hasConceptScore W2318903071C153911025 @default.
- W2318903071 hasConceptScore W2318903071C178666793 @default.
- W2318903071 hasConceptScore W2318903071C190283241 @default.
- W2318903071 hasConceptScore W2318903071C389152 @default.
- W2318903071 hasConceptScore W2318903071C53345823 @default.
- W2318903071 hasConceptScore W2318903071C54355233 @default.
- W2318903071 hasConceptScore W2318903071C54458228 @default.