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• W2318904513 abstract "Genetically modified replication-selective human adenoviruses are currently undergoing testing in the clinical setting as anticancer agents. Coupling the lytic function of these viruses with virus-mediated transgene delivery represents a powerful extension of this treatment. We have designed a unique system for gene delivery from the replicating virus. It takes advantage of the endogenous gene expression control sequences (promoter, splicing, polyadenylation signals) to efficiently and predictably deliver transgenes from the non-essential E3 transcription unit while still maintaining the expression of the remaining E3 genes in the multi-gene transcription unit. In this article, we engineered restriction enzyme sites into the virus genome selectively to delete the ADP gene and replace it with the therapeutic transgenes CD and TNFalpha. We demonstrate that: (1) transgene expression from this region mirrors the substituted ADP gene; (2) the loss of ADP in these viruses results in infected cells with extended viability and protein synthesis when compared with a wild-type Ad5 infected cell; and (3) expression of surrounding E3 genes can be maintained in such a system. The potential advantages of delivering transgenes from the ADP region of the replicating adenovirus are discussed." @default.
• W2318904513 created "2016-06-24" @default.
• W2318904513 creator A5041529060 @default.
• W2318904513 creator A5079065615 @default.
• W2318904513 date "2001-08-01" @default.
• W2318904513 modified "2023-09-26" @default.
• W2318904513 title "Gene delivery from the E3 region of replicating human adenovirus: evaluation of the ADP region" @default.
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• W2318904513 doi "https://doi.org/10.1038/sj.gt.3301508" @default.
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