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- W2319022795 abstract "Mucosal ImmunologyEpithelial cells line the intestinal tract and help to keep the peace between our immune system and our trillions of gut microbes. Such peacekeeping requires glycosylated proteins (proteins with attached carbohydrate chains) present on the epithelial cell surface, but how glycosylation occurs is unclear. Goto et al. find that fucosylation (a type of glycosylation) of gut epithelial cells in mice requires gut microbes (see the Perspective by Hooper). This process also requires innate lymphoid cells there, which produce the cytokines interleukin-22 and lymphotoxin, presumably in response to microbial signals. These cytokines signal epithelial cells to add fucose to membrane proteins, which allows the detente between microbes and immune cells to continue.Science , this issue [10.1126/science.1254009][1]; see also p. [1248][2] [1]: /lookup/doi/10.1126/science.1254009 [2]: /lookup/volpage/345/1248?iss=6202" @default.
- W2319022795 created "2016-06-24" @default.
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- W2319022795 date "2014-09-11" @default.
- W2319022795 modified "2023-09-24" @default.
- W2319022795 title "Immune cells and bugs make a sugary coat" @default.
- W2319022795 doi "https://doi.org/10.1126/science.345.6202.1306-n" @default.
- W2319022795 hasPublicationYear "2014" @default.
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