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- W2319075319 abstract "Background: Age-related differences in response to pain stimuli remain a controversial issue. The purpose of this study was to evaluate the effect of age on pain response using the formalin treated rats and streptozotin-induced diabetic rats tested for mechnical, cold allodynia and thermal hyperalgesia. Methods: We divided Sprague-Dawley rats into 3 groups by age, 5 weeks old (n = 10), 8 weeks old (n = 10), 12 weeks old (n = 10). Each group was divided into 2 subgroups (n = 5). One was formalin tested and the other was injected with streptozotin 75 mg intraperitoneally for succesive two days. On the 3rd day after injection, we examined mechnical allodynia using a von Frey filament, and tested thermal hyperalgesia using a tail immersion test in 50 or 5 water. Results: In the formalin test, pain response was higher in the younger age group (P in-induced diabetic rats, no difference in mechanical allodynia was observed between the subgroups. In the 50 water thermal hyperalgesia test, withdrawal latency decreased in each group after streptozotin injection (P water cold allodynia test, the 5-week animals showed a lower withdrawal latency than the other age groups (P" @default.
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- W2319075319 date "2004-01-01" @default.
- W2319075319 modified "2023-09-29" @default.
- W2319075319 title "Effect of Age on Response to Pain Stimuli in Rats" @default.
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- W2319075319 doi "https://doi.org/10.4097/kjae.2004.46.4.475" @default.
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