Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319093696> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2319093696 endingPage "A94" @default.
- W2319093696 startingPage "A93" @default.
- W2319093696 abstract "<h3>Background</h3> One-third of the world9s population is thought to be infected with Mycobacterium tuberculosis (Mtb); the highest incidence rates for active disease are found in the WHO9s South-East Asian and African regions. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) each infect about 0.3% of the UK population. HBV/HCV are treatable but largely asymptomatic until advanced liver disease and/or cancer. Screening for HBV/HCV is recommended in high-risk individuals but is not routinely performed in TB patients. HBV/HCV share similar epidemiological “hotspots” to TB, and several studies, primarily in South America and East Asia, have shown an increased prevalence of HBV/HCV in TB patients and an association between HBV/HCV and Drug Induced Liver Injury (DILI) following anti-TB therapy. No such analysis has been performed in the UK. <h3>Aims</h3> To assess The prevalence of markers of HBV and HCV infection in patients undergoing anti-TB therapy. Whether serological evidence of HBV/HCV increases risk of DILI. <h3>Method</h3> A prospective study on 429 TB patients receiving anti-TB therapy in a diverse urban TB clinic. Serological markers of HBV/HCV/HIV infection were documented. ALT was measured prior to treatment and 2–4 weeks after treatment initiation. DILI was defined as an ALT rise of greater than 2-times upper limit of normal following a normal pre-treatment level (<40 IU/ml). <h3>Results</h3> 58.7% of patients were from either South-East Asia or Africa. 61 (14.2%) patients were isolated anti-HBc antibody positive (Anti-HBc), 11 (2.6%) were Hepatitis B surface antigen positive (HBsAg) and 7 (1.6%) were HCV antibody positive. The prevalence of active HBV/HCV infection was significantly higher than the estimated UK prevalence in this urban TB clinic. Three (5.3%) patients with serological evidence of HBV/HCV had DILI compared to 25 (9.5%) of those without. <h3>Conclusion</h3> HBV/HCV prevalence is higher among TB patients and routine screening for viral hepatitis should be considered in this group. DILI was not increased in patients with serological markers of HBV/HCV." @default.
- W2319093696 created "2016-06-24" @default.
- W2319093696 creator A5023723918 @default.
- W2319093696 creator A5027623234 @default.
- W2319093696 creator A5048388773 @default.
- W2319093696 creator A5054519729 @default.
- W2319093696 creator A5056907164 @default.
- W2319093696 creator A5064420382 @default.
- W2319093696 creator A5067154431 @default.
- W2319093696 creator A5077157406 @default.
- W2319093696 creator A5083477161 @default.
- W2319093696 creator A5085092701 @default.
- W2319093696 date "2011-12-01" @default.
- W2319093696 modified "2023-09-26" @default.
- W2319093696 title "P63 The prevalence of viral hepatitis in patients undergoing anti-tuberculous therapy" @default.
- W2319093696 doi "https://doi.org/10.1136/thoraxjnl-2011-201054c.63" @default.
- W2319093696 hasPublicationYear "2011" @default.
- W2319093696 type Work @default.
- W2319093696 sameAs 2319093696 @default.
- W2319093696 citedByCount "0" @default.
- W2319093696 crossrefType "journal-article" @default.
- W2319093696 hasAuthorship W2319093696A5023723918 @default.
- W2319093696 hasAuthorship W2319093696A5027623234 @default.
- W2319093696 hasAuthorship W2319093696A5048388773 @default.
- W2319093696 hasAuthorship W2319093696A5054519729 @default.
- W2319093696 hasAuthorship W2319093696A5056907164 @default.
- W2319093696 hasAuthorship W2319093696A5064420382 @default.
- W2319093696 hasAuthorship W2319093696A5067154431 @default.
- W2319093696 hasAuthorship W2319093696A5077157406 @default.
- W2319093696 hasAuthorship W2319093696A5083477161 @default.
- W2319093696 hasAuthorship W2319093696A5085092701 @default.
- W2319093696 hasBestOaLocation W23190936961 @default.
- W2319093696 hasConcept C107130276 @default.
- W2319093696 hasConcept C120665830 @default.
- W2319093696 hasConcept C121332964 @default.
- W2319093696 hasConcept C126322002 @default.
- W2319093696 hasConcept C142724271 @default.
- W2319093696 hasConcept C159047783 @default.
- W2319093696 hasConcept C159654299 @default.
- W2319093696 hasConcept C203014093 @default.
- W2319093696 hasConcept C2522874641 @default.
- W2319093696 hasConcept C2776408679 @default.
- W2319093696 hasConcept C2776455275 @default.
- W2319093696 hasConcept C2777072776 @default.
- W2319093696 hasConcept C2777075537 @default.
- W2319093696 hasConcept C2777382497 @default.
- W2319093696 hasConcept C2777910003 @default.
- W2319093696 hasConcept C2780593183 @default.
- W2319093696 hasConcept C2781069245 @default.
- W2319093696 hasConcept C2908647359 @default.
- W2319093696 hasConcept C45189115 @default.
- W2319093696 hasConcept C61511704 @default.
- W2319093696 hasConcept C71924100 @default.
- W2319093696 hasConcept C99454951 @default.
- W2319093696 hasConceptScore W2319093696C107130276 @default.
- W2319093696 hasConceptScore W2319093696C120665830 @default.
- W2319093696 hasConceptScore W2319093696C121332964 @default.
- W2319093696 hasConceptScore W2319093696C126322002 @default.
- W2319093696 hasConceptScore W2319093696C142724271 @default.
- W2319093696 hasConceptScore W2319093696C159047783 @default.
- W2319093696 hasConceptScore W2319093696C159654299 @default.
- W2319093696 hasConceptScore W2319093696C203014093 @default.
- W2319093696 hasConceptScore W2319093696C2522874641 @default.
- W2319093696 hasConceptScore W2319093696C2776408679 @default.
- W2319093696 hasConceptScore W2319093696C2776455275 @default.
- W2319093696 hasConceptScore W2319093696C2777072776 @default.
- W2319093696 hasConceptScore W2319093696C2777075537 @default.
- W2319093696 hasConceptScore W2319093696C2777382497 @default.
- W2319093696 hasConceptScore W2319093696C2777910003 @default.
- W2319093696 hasConceptScore W2319093696C2780593183 @default.
- W2319093696 hasConceptScore W2319093696C2781069245 @default.
- W2319093696 hasConceptScore W2319093696C2908647359 @default.
- W2319093696 hasConceptScore W2319093696C45189115 @default.
- W2319093696 hasConceptScore W2319093696C61511704 @default.
- W2319093696 hasConceptScore W2319093696C71924100 @default.
- W2319093696 hasConceptScore W2319093696C99454951 @default.
- W2319093696 hasIssue "Suppl 4" @default.
- W2319093696 hasLocation W23190936961 @default.
- W2319093696 hasLocation W23190936962 @default.
- W2319093696 hasOpenAccess W2319093696 @default.
- W2319093696 hasPrimaryLocation W23190936961 @default.
- W2319093696 hasRelatedWork W1497171619 @default.
- W2319093696 hasRelatedWork W2074143794 @default.
- W2319093696 hasRelatedWork W2124774996 @default.
- W2319093696 hasRelatedWork W2156800310 @default.
- W2319093696 hasRelatedWork W2286361385 @default.
- W2319093696 hasRelatedWork W2432600830 @default.
- W2319093696 hasRelatedWork W2767728061 @default.
- W2319093696 hasRelatedWork W2888960221 @default.
- W2319093696 hasRelatedWork W2994718415 @default.
- W2319093696 hasRelatedWork W4254961128 @default.
- W2319093696 hasVolume "66" @default.
- W2319093696 isParatext "false" @default.
- W2319093696 isRetracted "false" @default.
- W2319093696 magId "2319093696" @default.
- W2319093696 workType "article" @default.