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- W2319102658 abstract "A case of microangiopathic hemolytic anemia (MHA) associated with disseminated breast cancer is reported. A 57-year-old woman was admitted for evaluation of a tumor of the left breast. She had had lumbago for about 6 months prior to the admission. A few days after the admission, she received red blood cell transfusion and she developed a bout of hemolysis immediately after that. The hematological examinations showed hemolytic anemia in association with severe red blood cell fragmentation and leukoerythroblastosis. While clotting abnormalities or thrombocytopenia was quite mild at the height of the hemolytic crisis. On the other hand, the histology of the left breast tumor revealed papillotubular adenocarcinoma and the Ga-citrate scintigram showed diffuse RI uptake at the spine especially in the lumbar region. Taken altogether, she was diagnosed as having disseminated breast cancer and MHA without disseminated intravascular coagulation (DIC). Then she was started on combination chemotherapy using CMFVP regimen, and anti-estrogen therapy. About 4 months later, MHA was brought to remission with the remarkable reduction of the tumor bulk at both the primary and metastatic sites, and she was discharged. A month after that, however, she entered the hospital again because of the rapid progression of anemia attributable to relapsing MHA. On the 17th hospital day of this admission she died of respiratory failure.The autopsy disclosed diffusely infiltrative, though partly nodular, metastatic tumor growth of thoracic and lumbar vertebrae. In addition, there were a number of tumor emboli in the small vessels of both lungs and severe cryptococcal infection in both pulmonary bases as well. But there were no thrombi formation in any organs to suggest the presence of DIC.To conclude, the case depicted here is quite intriguing in view of the pathogenesis of MHA unassociated with DIC, unfavorable effect of blood transfusion for MHA and the possible efficacy of chemotherapy against malignancy-related MHA." @default.
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- W2319102658 date "1988-01-01" @default.
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- W2319102658 title "An autopsied case of microangiopathic hemolytic anemia associated with disseminated breast cancer which responded well to anti-cancer chemotherapy. As a rare complication of blood transfusion." @default.
- W2319102658 doi "https://doi.org/10.3925/jjtc1958.34.344" @default.
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