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• W2319179997 abstract "This study compared the whole cell proteome profiles of two isogenic colorectal cancer (CRC) cell lines (primary SW480 cell line and its lymph node metastatic variant SW620), as an in vitro metastatic model, to gain an insight into the molecular events of CRC metastasis. Using iTRAQ (isobaric tags for relative and absolute quantitation) based shotgun proteomics approach, we identified 1140 unique proteins, out of which 147 were found to be significantly altered in the metastatic cell. Ingenuity pathway analysis with those significantly altered proteins, revealed cellular organization and assembly as the top-ranked altered biological function. Differential expression pattern of 6 candidate proteins were validated by Western blot. Among these, the low expression level of β-catenin combined with the up-regulation of CacyBP (Calcyclin binding Protein), a β-catenin degrading protein, in the metastatic cell provided a rational guide for the downstream functional assays. The relative expression pattern of these two proteins was further validated in three other CRC cells by Western blot and quantitative immunofluorescence studies. Overexpression of CacyBP in three different primary CRC cell lines showed significant reduction in adhesion characteristics as well as cellular β-catenin level as confirmed by our experiments, indicating the possible involvement of CacyBP in CRC metastasis. In short, this study demonstrates successful application of a quantitative proteomics approach to identify novel key players for CRC metastasis, which may serve as biomarkers and/or drug targets to improve CRC therapy." @default.
• W2319179997 created "2016-06-24" @default.
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• W2319179997 date "2011-09-19" @default.
• W2319179997 modified "2023-10-18" @default.
• W2319179997 title "Identification of Key Players for Colorectal Cancer Metastasis by iTRAQ Quantitative Proteomics Profiling of Isogenic SW480 and SW620 Cell Lines" @default.
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• W2319179997 cites W1969616058 @default.
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• W2319179997 cites W1972234366 @default.
• W2319179997 cites W1975406254 @default.
• W2319179997 cites W1981752846 @default.
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• W2319179997 cites W2077237370 @default.
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• W2319179997 cites W2084555620 @default.
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• W2319179997 cites W2094268545 @default.
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• W2319179997 doi "https://doi.org/10.1021/pr2005617" @default.
• W2319179997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21854069" @default.
• W2319179997 hasPublicationYear "2011" @default.
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