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- W2319220337 abstract "Blood tests of immune cell levels in AIDS patients were endorsed by a high-level panel last week as substitutes for drug efficacy tests that are more definitive but delay new drug approvals. At a conference sponsored by the Institute of Medicine in Washington, D.C., the panel particularly cited blood levels of CD4 lymphocyte cells as the best surrogate marker to augment or replace other indicators in efficacy trials of new AIDS drugs. Patient survival rates and frequency of opportunistic infections are that the Food & Drug Administration currently accepts as evidence of drug effectiveness. But these tests are slow, tending to keep potentially beneficial drugs out of the hands of desperate patients for long periods while trials proceed. Surrogate endpoints could be evaluated more quickly, thus speeding drug approvals. Of several surrogates under consideration, the CD4 marker is now furthest along for use in clinical AIDS trials, according to Anthony S. Fauci, director ..." @default.
- W2319220337 created "2016-06-24" @default.
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- W2319220337 date "1989-09-18" @default.
- W2319220337 modified "2023-10-17" @default.
- W2319220337 title "New approach may speed AIDS drug trials" @default.
- W2319220337 doi "https://doi.org/10.1021/cen-v067n038.p006a" @default.
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