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- W2319241000 abstract "Biogen Idec on February 27 announced the approval of dimethyl fumarate delayed-release oral capsules for the treatment of relapsing forms of multiple sclerosis. The drug will be available under the brand name Tecfidera, according to the company. The labeling for dimethyl fumarate states that after ingestion, the drug is rapidly converted to its active metabolite, monomethyl fumarate. The drug’s mechanism of action is unknown but may be related to the activation of a pathway involved in cells’ response to oxidative stress. In two placebo-controlled clinical trials involving patients with relapsing forms of multiple sclerosis, those treated with dimethyl fumarate had less disease activity, with fewer relapses, fewer or less severe neurologic lesions, and, in one study, less disease progression. The most frequently reported adverse events associated with dimethyl fumarate use were flushing, which affected about 40% of clinical trial participants, and gastrointestinal symptoms, according to the drug’s labeling. Administration of the drug with food may reduce flushing, the labeling states." @default.
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- W2319241000 date "2013-05-01" @default.
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- W2319241000 title "Oral therapy approved for multiple sclerosis" @default.
- W2319241000 doi "https://doi.org/10.2146/news130031" @default.
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