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- W2319314151 abstract "Purpose: We investigated the effect of cardiac-targeting erythropoietin (EPO)-encapsulated liposomes with Sialyl Lewis X (SLX) on myocardial infarct (MI) size, left ventricular (LV) remodeling and function, and its molecular mechanism for repairing infarcted myocardium.Methods: In rabbits, myocardial infarction (MI) was induced by 30 min coronary occlusion followed by reperfusion. EPO-encapsulated liposomes with SLX (L-EPO group), EPO-encapsulated liposomes without SLX (L-EPO without SLX group), liposomes with SLX without EPO (L group), or saline (Saline group) were intravenously administered immediately after MI. The MI size and the number of microvessels were assessed at 14 days after MI. Prosurvival proteins and signals were assessed by western blot analysis at 2 and 14 days after MI.Results: Confocal microscopy and electron microscopy showed the specific accumulation of liposomes with SLX in the infarcted myocardium. The MI and cardiac fibrosis areas were significantly smaller in the L-EPO group than the other groups. The LV function and remodeling were improved in the L-EPO group. The number of CD31-positive microvessels was significantly greater in the L-EPO group than in the other groups. Higher expressions of EPO receptors, phosphorylated (p)-Akt, p-ERK, p-Stat3, VEGF, Bcl-2 and pro-MMP-1 were observed in the infarct area in the L-EPO group than in the other groups.Conclusions: The EPO-encapsulated liposomes with SLX selectively accumulated in the infarct area and reduced MI size and improved LV remodeling and function through activation of prosurvival signals and by exerting antifibrotic and angiogenic effects. EPO-encapsulated liposomes with SLX may be a promising strategy for active targeting treatment of acute MI." @default.
- W2319314151 created "2016-06-24" @default.
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- W2319314151 date "2013-08-02" @default.
- W2319314151 modified "2023-09-28" @default.
- W2319314151 title "Post-infarct administration of erythropoietin-encapsulated liposomes with Sialyl Lewis X (SLX) but not without SLX repairs infarcted myocardium in rabbits" @default.
- W2319314151 doi "https://doi.org/10.1093/eurheartj/eht309.p4189" @default.
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