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- W2319315665 abstract "The so-called mink strains of canine distemper virus isolated by the authors were subjected to serial passages through the chorioallantoic membranes of seven-day embryonating hen's eggs. As a result, two of the five strains used acquired adaptability to and lost pathogenicity for embryonating eggs when they had reached the 20th and the 35th passage, respectively. The resulting avianized live virus was inoculated into minks and dogs to confirm its safety. The high immunogenicity of this virus was proved in these animals which had been challenged with distemper virus or which had been exposed to contact with infected animals of the same species after vaccination with avianized virus. Therefore, it was made clear that this adapted virus was available to prepare very effective vaccine.Dried vaccine was prepared experimentally from avianized virus. After storage at 4°C for 12 months, this vaccine still contained live virus, which was demonstrated by inoculation experiments on the chorioallantoic membrane. Satisfactory results were also obtained from mass inoculation of dogs in the field.It was confirmed that the avianized live virus isolated by the authors was identical with the Lederle strain and other known chick-embryo-adapted live virus strains with regard to antigen when examined by cross immunization tests." @default.
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- W2319315665 date "1961-01-01" @default.
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- W2319315665 title "Studies on Immunization against Distemper" @default.
- W2319315665 doi "https://doi.org/10.12935/jvma1951.14.433" @default.
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