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• W2319327386 abstract "We previously reported that a priming dose of 0.3 Gy on gestation day 11 significantly increased the rate of living fetuses and reduced the incidence of congenital malformations caused by exposure to 5 Gy X rays on gestation day 12 in ICR mice. In the present study, postnatal development of the live offspring was investigated using a set of developmental and behavioral parameters. The offspring of the mice irradiated with 0.3 Gy generally showed a delay in the appearance of most of the physiological markers, impaired acquisition of neonatal reflexes, and alteration of adult behavior. However, an increase in body weight in the females was observed 4 weeks postnatally. In the offspring primed with 0.3 Gy followed by a challenging dose of 5 Gy prenatally, a high postnatal mortality was found, and all the survivors had various radiation-induced detrimental effects. The results indicated that the priming dose was advantageous to survival itself, but was disadvantageous to the health of survivor. The results also suggested that studying the whole animal can show the extent of the effects of radiation, i.e. quality of life, in a way that cellular or molecular studies cannot." @default.
• W2319327386 created "2016-06-24" @default.
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• W2319327386 date "1999-08-01" @default.
• W2319327386 modified "2023-09-26" @default.
• W2319327386 title "Adaptive Response in Embryogenesis: II. Retardation of Postnatal Development of Prenatally Irradiated Mice" @default.
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• W2319327386 doi "https://doi.org/10.2307/3580084" @default.
• W2319327386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10409320" @default.
• W2319327386 hasPublicationYear "1999" @default.
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