FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319328535> ?p ?o ?g. }

• W2319328535 endingPage "33" @default.
• W2319328535 startingPage "21" @default.
• W2319328535 abstract "Betel leaf combined with areca nut is known as betel quid pan masala (PM), and tobacco with areca nut, catechu and lime is pan masala (PMT) blended with gulkhand. These narcotics are popular among young and old individuals. A prima facia chemical analysis and a toxicity assessment of PM in mice were conducted to study the relationship between longtime consumption of PM and health hazards.Chemical analysis of different types of PM was done employing HPLC, GLC, AAS, ES, TLC, GCMS and sequential extraction for PAH, pesticides, metals and minerals, electrolytes, drugs and xenobiotics. Ethanolic PM extracts were tested by IP and PO routes in inbred Swiss mice.PAH, which are known xenobiotics for pre-cancerous lesions, were significantly high (p<0.01) in Rajaniganda and Pan Parag Zarda. Isomers of DDT and BHC, which principally act on nerves and muscles, were also high (p<0.01) in PM. The enhanced metal and mineral content of PM results in massive oral fibrosis. There is a high level of narcotics in PM, especially nicotine, a potentially cancerous agent in the gastrointestinal tract.Experimental studies with different extracts of plain and blended PM in mice fed for 16 and 90 days revealed no effect on blood and organ weights (kidney, heart, spleen and liver), but we did observe attenuated testis. However, in the bone marrow of the mice, chromosomes were most affected in the mice fed PM-Zarda blend for 3 months. The chromosomal abnormalities included ploidy, loss, breaks, gaps, deletions and exchanges in ring chromosomes. The PM caused sperm head anomalies (narrow, blunt, triangular and banana shapes), and the sperm were irregular, amorphous, tailless and rudimentary, with the maximum effect among the groups fed PM for 3 months. Significantly higher levels (p<0.01) of testis glycogen, cholesterol and protein were found. The group fed for 16 days showed no change in red blood corpuscles (RBC), white blood corpuscles (WBC), hemoglobin and erythrocyte sedimentation counts.Areka fındık ile kombine betel yaprağı pan masala (PM) ve areka fındık ile tütün, pekiştirici ve kireç gulkhand ile harmanlanmış pan masala (PMT) olarak bilinir. Bunlar genç ve yaşlı bireyler arasında popüler uyuşturucu maddelerdir. PM bir toksisite değerlendirilmesi prima facia kimyasal analiz ve farelerde uzun zamandır PM tüketimi ve sağlık riskleri arasındaki ilişkiyi incelemek için gerçekleştirilmiştir.Farklı kimyasal analizler; PM HPLC, GLC, AAS, ES, TLC, GCMS ve PAH, pestisitler, metaller ve mineraller, elektrolitler, uyuşturucu ve ksenobiyotiklere için sıralı ekstraksiyon ile gerçekleştirilmiştir. Etanolik PM özleri inbred Swiss farelerde IP ve PO yollar ile test edilmiştir.Kanser öncesi lezyonlar için ksenobiyotikler olarak bilinen PAH, Rajaniganda ve Pan Parag Zarda’da (p <0.01) anlamlı olarak yüksek bulunmuştur. Başta sinir ve kasların hareket DDT ve BHC, izomerleri PM (p <0.01) yüksek bulunmuştur. Masif oral fibrozis PM sonuçlarının gelişmiş metal ve mineral içeriği, gastrointestinal sistemin potansiyel kanser ajanı, özellikle nikotin PM uyuşturucuda yüksek düzeyde bulunmaktadır.Deneysel çalışmalarda 16 ve 90 gün boyunca beslenen farelerde düz ve karışımlı PM farklı özlerinin kan ve organ ağırlıkları (böbrek, kalp, dalak ve karaciğer) üzerinde hiçbir etkisi yoktur, ancak ufalmış testis gözlemlemek mümkün olmuştur. Ancak, PM-Zarda karışımı ile 3 ay boyunca beslenen farelerin kemik iliğinde, kromozomlar büyük oranda etkilenmiştir. Kromozom anomalilerine ploidi, kayıp, boşluk, silinme ve halka kromozomlar içerisinde değişim dahildir. PM sperm baş anomalileri (dar, künt, üçgen ve muz şekiller) ve 3 ay boyunca PM ile beslenen gruplar arasındaki maksimum etkisi ile sperm düzensiz amorf, kuyruksuz ve ilkel yapısı şeklinde gözlemlenmiştir. Testis glikojen, kolesterol ve protein düzeyleri arasında anlamlı (p <0.01) ilişki bulunmuştur. PM ile 16 gün boyunca beslenen grupta alyuvar (RBC), akyuvar (WBC), hemoglobin ve eritrosit sedimentasyon sayımlarında hiçbir değişiklik gözlenmemiştir." @default.
• W2319328535 created "2016-06-24" @default.
• W2319328535 creator A5075650400 @default.
• W2319328535 creator A5085583905 @default.
• W2319328535 date "2013-02-01" @default.
• W2319328535 modified "2023-09-30" @default.
• W2319328535 title "Analysis and Toxicity of Plain (PMP) and Blended (PMT) Indian Pan Masala (PM)" @default.
• W2319328535 cites W1506043065 @default.
• W2319328535 cites W1965071342 @default.
• W2319328535 cites W1966734873 @default.
• W2319328535 cites W1988592017 @default.
• W2319328535 cites W1990522285 @default.
• W2319328535 cites W1993260016 @default.
• W2319328535 cites W2027425231 @default.
• W2319328535 cites W2031190347 @default.
• W2319328535 cites W2033831167 @default.
• W2319328535 cites W2063992475 @default.
• W2319328535 cites W2067773736 @default.
• W2319328535 cites W2070873743 @default.
• W2319328535 cites W2130589095 @default.
• W2319328535 cites W2405340985 @default.
• W2319328535 cites W2432809910 @default.
• W2319328535 cites W2461622860 @default.
• W2319328535 cites W2464047253 @default.
• W2319328535 cites W4290437257 @default.
• W2319328535 cites W4290665306 @default.
• W2319328535 doi "https://doi.org/10.5152/eajm.2013.04" @default.
• W2319328535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4261503" @default.
• W2319328535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25610244" @default.
• W2319328535 hasPublicationYear "2013" @default.
• W2319328535 type Work @default.
• W2319328535 sameAs 2319328535 @default.
• W2319328535 citedByCount "9" @default.
• W2319328535 countsByYear W23193285352014 @default.
• W2319328535 countsByYear W23193285352015 @default.
• W2319328535 countsByYear W23193285352017 @default.
• W2319328535 countsByYear W23193285352019 @default.
• W2319328535 countsByYear W23193285352020 @default.
• W2319328535 countsByYear W23193285352022 @default.
• W2319328535 countsByYear W23193285352023 @default.
• W2319328535 crossrefType "journal-article" @default.
• W2319328535 hasAuthorship W2319328535A5075650400 @default.
• W2319328535 hasAuthorship W2319328535A5085583905 @default.
• W2319328535 hasBestOaLocation W23193285351 @default.
• W2319328535 hasConcept C126322002 @default.
• W2319328535 hasConcept C127413603 @default.
• W2319328535 hasConcept C206391251 @default.
• W2319328535 hasConcept C2778622267 @default.
• W2319328535 hasConcept C2779741799 @default.
• W2319328535 hasConcept C29730261 @default.
• W2319328535 hasConcept C33070731 @default.
• W2319328535 hasConcept C42407357 @default.
• W2319328535 hasConcept C556039675 @default.
• W2319328535 hasConcept C66938386 @default.
• W2319328535 hasConcept C71924100 @default.
• W2319328535 hasConcept C86803240 @default.
• W2319328535 hasConcept C98274493 @default.
• W2319328535 hasConceptScore W2319328535C126322002 @default.
• W2319328535 hasConceptScore W2319328535C127413603 @default.
• W2319328535 hasConceptScore W2319328535C206391251 @default.
• W2319328535 hasConceptScore W2319328535C2778622267 @default.
• W2319328535 hasConceptScore W2319328535C2779741799 @default.
• W2319328535 hasConceptScore W2319328535C29730261 @default.
• W2319328535 hasConceptScore W2319328535C33070731 @default.
• W2319328535 hasConceptScore W2319328535C42407357 @default.
• W2319328535 hasConceptScore W2319328535C556039675 @default.
• W2319328535 hasConceptScore W2319328535C66938386 @default.
• W2319328535 hasConceptScore W2319328535C71924100 @default.
• W2319328535 hasConceptScore W2319328535C86803240 @default.
• W2319328535 hasConceptScore W2319328535C98274493 @default.
• W2319328535 hasIssue "1" @default.
• W2319328535 hasLocation W23193285351 @default.
• W2319328535 hasLocation W23193285352 @default.
• W2319328535 hasLocation W23193285353 @default.
• W2319328535 hasLocation W23193285354 @default.
• W2319328535 hasOpenAccess W2319328535 @default.
• W2319328535 hasPrimaryLocation W23193285351 @default.
• W2319328535 hasRelatedWork W2236445294 @default.
• W2319328535 hasRelatedWork W2310432204 @default.
• W2319328535 hasRelatedWork W2315813840 @default.
• W2319328535 hasRelatedWork W2433394682 @default.
• W2319328535 hasRelatedWork W2966746224 @default.
• W2319328535 hasRelatedWork W2982868786 @default.
• W2319328535 hasRelatedWork W2995313518 @default.
• W2319328535 hasRelatedWork W4297786558 @default.
• W2319328535 hasRelatedWork W4360969505 @default.
• W2319328535 hasRelatedWork W2763088423 @default.
• W2319328535 hasVolume "45" @default.
• W2319328535 isParatext "false" @default.
• W2319328535 isRetracted "false" @default.
• W2319328535 magId "2319328535" @default.
• W2319328535 workType "article" @default.