FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319329079> ?p ?o ?g. }

• W2319329079 endingPage "1986" @default.
• W2319329079 startingPage "1981" @default.
• W2319329079 abstract "Objective: Successful antiretroviral therapy (ART) suppresses plasma HIV-1 RNA below detection limits, reducing the chronic insult to the immune systems of infected individuals and supporting a degree of immunological recovery. However, the surface phenotypic profile of T cells in ART-treated patients does not resemble that of healthy, uninfected individuals, but rather shows upregulation of proteins associated with an exhausted immune system. We sought to address whether aviraemic HIV-1 infection, therefore, contributed to long-term alterations in intracellular signalling events within the T cells of infected individuals that contributed to the exhausted phenotype. Design: A flow cytometric approach was employed to assess levels of phosphorylation within T-cell signalling proteins in ART-treated HIV-1-positive patients and HIV-negative individuals. Methods: The relative phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38, zeta-chain-associated protein kinase 70 (ZAP70), linker of activated T cells, SLP76, nuclear factor kappaB were measured within resting and stimulated CD4+ and CD8+ T cells from aviraemic HIV-1-positive and healthy individuals by intracellular staining and flow cytometric analysis. Results: Basal levels of phospho-ZAP70, phospho-ERK and phospho-JNK were two-fold to three-fold higher in HIV-1-positive individuals compared with healthy controls, with phospho-p38 also showing a tendency to increase in HIV-1-positive individuals. Interestingly, in contrast to healthy controls, peripheral blood mononuclear cells from aviraemic, infected individuals were refractory to stimulation with IL-2 and CD3/CD28 showing no enhancement of phosphorylation. Conclusion: CD4+ and CD8+ T cells from HIV-1-positive individuals are poorly responsive to direct stimulation through the T-cell receptor due to chronically raised basal activation levels of intracellular signalling molecules." @default.
• W2319329079 created "2016-06-24" @default.
• W2319329079 creator A5006623516 @default.
• W2319329079 creator A5026962388 @default.
• W2319329079 creator A5054671965 @default.
• W2319329079 creator A5064394016 @default.
• W2319329079 creator A5067110504 @default.
• W2319329079 creator A5070905694 @default.
• W2319329079 date "2011-10-23" @default.
• W2319329079 modified "2023-10-18" @default.
• W2319329079 title "T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness" @default.
• W2319329079 cites W1494391045 @default.
• W2319329079 cites W1585131743 @default.
• W2319329079 cites W1965845165 @default.
• W2319329079 cites W1967075274 @default.
• W2319329079 cites W1972669264 @default.
• W2319329079 cites W1985273612 @default.
• W2319329079 cites W2001815433 @default.
• W2319329079 cites W2003437163 @default.
• W2319329079 cites W2029501967 @default.
• W2319329079 cites W2042900104 @default.
• W2319329079 cites W2068398543 @default.
• W2319329079 cites W2084873532 @default.
• W2319329079 cites W2087968561 @default.
• W2319329079 cites W2093748939 @default.
• W2319329079 cites W2098912737 @default.
• W2319329079 cites W2114119969 @default.
• W2319329079 cites W2126842066 @default.
• W2319329079 cites W2140712036 @default.
• W2319329079 cites W2159000465 @default.
• W2319329079 cites W2162457545 @default.
• W2319329079 cites W2164980005 @default.
• W2319329079 cites W2167148984 @default.
• W2319329079 doi "https://doi.org/10.1097/qad.0b013e32834b35a9" @default.
• W2319329079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21811141" @default.
• W2319329079 hasPublicationYear "2011" @default.
• W2319329079 type Work @default.
• W2319329079 sameAs 2319329079 @default.
• W2319329079 citedByCount "4" @default.
• W2319329079 countsByYear W23193290792012 @default.
• W2319329079 countsByYear W23193290792013 @default.
• W2319329079 countsByYear W23193290792014 @default.
• W2319329079 countsByYear W23193290792016 @default.
• W2319329079 crossrefType "journal-article" @default.
• W2319329079 hasAuthorship W2319329079A5006623516 @default.
• W2319329079 hasAuthorship W2319329079A5026962388 @default.
• W2319329079 hasAuthorship W2319329079A5054671965 @default.
• W2319329079 hasAuthorship W2319329079A5064394016 @default.
• W2319329079 hasAuthorship W2319329079A5067110504 @default.
• W2319329079 hasAuthorship W2319329079A5070905694 @default.
• W2319329079 hasBestOaLocation W23193290791 @default.
• W2319329079 hasConcept C11960822 @default.
• W2319329079 hasConcept C137061746 @default.
• W2319329079 hasConcept C148125776 @default.
• W2319329079 hasConcept C154317977 @default.
• W2319329079 hasConcept C167672396 @default.
• W2319329079 hasConcept C184235292 @default.
• W2319329079 hasConcept C196166836 @default.
• W2319329079 hasConcept C202751555 @default.
• W2319329079 hasConcept C203014093 @default.
• W2319329079 hasConcept C2776090121 @default.
• W2319329079 hasConcept C51551487 @default.
• W2319329079 hasConcept C553184892 @default.
• W2319329079 hasConcept C55493867 @default.
• W2319329079 hasConcept C57074206 @default.
• W2319329079 hasConcept C79879829 @default.
• W2319329079 hasConcept C86803240 @default.
• W2319329079 hasConcept C8891405 @default.
• W2319329079 hasConcept C95444343 @default.
• W2319329079 hasConceptScore W2319329079C11960822 @default.
• W2319329079 hasConceptScore W2319329079C137061746 @default.
• W2319329079 hasConceptScore W2319329079C148125776 @default.
• W2319329079 hasConceptScore W2319329079C154317977 @default.
• W2319329079 hasConceptScore W2319329079C167672396 @default.
• W2319329079 hasConceptScore W2319329079C184235292 @default.
• W2319329079 hasConceptScore W2319329079C196166836 @default.
• W2319329079 hasConceptScore W2319329079C202751555 @default.
• W2319329079 hasConceptScore W2319329079C203014093 @default.
• W2319329079 hasConceptScore W2319329079C2776090121 @default.
• W2319329079 hasConceptScore W2319329079C51551487 @default.
• W2319329079 hasConceptScore W2319329079C553184892 @default.
• W2319329079 hasConceptScore W2319329079C55493867 @default.
• W2319329079 hasConceptScore W2319329079C57074206 @default.
• W2319329079 hasConceptScore W2319329079C79879829 @default.
• W2319329079 hasConceptScore W2319329079C86803240 @default.
• W2319329079 hasConceptScore W2319329079C8891405 @default.
• W2319329079 hasConceptScore W2319329079C95444343 @default.
• W2319329079 hasIssue "16" @default.
• W2319329079 hasLocation W23193290791 @default.
• W2319329079 hasLocation W23193290792 @default.
• W2319329079 hasOpenAccess W2319329079 @default.
• W2319329079 hasPrimaryLocation W23193290791 @default.
• W2319329079 hasRelatedWork W1547736903 @default.
• W2319329079 hasRelatedWork W196367670 @default.
• W2319329079 hasRelatedWork W1979464515 @default.
• W2319329079 hasRelatedWork W2029614856 @default.
• W2319329079 hasRelatedWork W2085109799 @default.
• W2319329079 hasRelatedWork W2366693890 @default.

• next