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- W2319330387 abstract "A group of 70 guinea pigs was randomly assigned to 5 lots. One lot was sensitized by a series of Aedes aegypti bites. The second lot received only Aedes atropalpus bites; the third, Anopheles stephensi; the fourth, Anopheles quadrimaculatus; and the fifth lot, no mosquito bites. After the sensitization period each guinea pig was given a test bite from each of the following: A. aegypti, A. atropalpus, A. quadrimaculatus, and A. stephensi. Immediate skin reactions were evaluated by measuring: (1) area of increased vascular permeability as indicated by diffusion of a serum protein coupling dye, Coomassie Blue, 20 min after initiation of bites; (2) area of wheal and flare at 1 hr after initiation of bites. Skin reactions to bites of the species used to sensitize the guinea pigs were significantly greater than reactions to bites of the other 3 species (heterologous or cross-reactions). Some heterologous reactions were significantly greater than other heterologous reactions and skin trauma reactions of control guinea pigs. Thus, bites of a single species can produce immediate hypersensitivity to more than one species of mosquito. The heterologous reactions indicate that oral secretion of some mosquito species share at least one common antigen with one or more species. The purpose was to sensitize guinea pigs by bites of a single mosquito species and then determine whether or not bites of other species induced immediate hypersensitive skin re-" @default.
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- W2319330387 date "1971-04-01" @default.
- W2319330387 modified "2023-09-28" @default.
- W2319330387 title "Skin Reaction Specificity of Guinea Pig Immediate Hypersensitivity to Bites of Four Mosquito Species" @default.
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- W2319330387 doi "https://doi.org/10.2307/3278051" @default.
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