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• W2319344011 abstract "Purpose of review Autoimmune epileptic encephalopathy is a potentially treatable neurological syndrome characterized by the coexistence of a neuronal antibody in serum and, often, cerebrospinal fluid. Patients present with combinations of seizures, neuropsychiatric features, movement disorder, and cognitive decline, but some patients have isolated seizures either at first presentation or during their illness. This review summarizes our current understanding of the roles of specific neuronal antibodies in epilepsy-related syndromes and aims to aid the clinician in diagnosis and treatment. Recent findings Antigen discovery methods in three neuroimmunology centres independently identified antibodies to different subunits of the γ amino butyric acid-A receptor; high levels of these antibodies were found mainly in patients with severe refractory seizures. These and other antibodies were also found in a proportion (<10%) of children and adults with epilepsy. A clinical study comparing immunotherapy in patients with autoantibodies or without an identified target antigen found neuroinflammatory features were predictive of a therapeutic response. New in-vitro and in-vivo studies, and spontaneous animal models, have confirmed the pathogenicity and epileptogenicity of neuronal antibodies and their relevance to other mammals. Summary Neuronal antibodies are an important cause of autoimmune epileptic encephalopathy, early recognition is important as there may be an underlying tumour, and early treatment is associated with a better outcome. In the absence of an antibody, the clinician should adopt a pragmatic approach and consider a trial of immunotherapy when other causes have been excluded." @default.
• W2319344011 created "2016-06-24" @default.
• W2319344011 creator A5011472181 @default.
• W2319344011 creator A5062939642 @default.
• W2319344011 date "2016-04-01" @default.
• W2319344011 modified "2023-10-17" @default.
• W2319344011 title "Progress in autoimmune epileptic encephalitis" @default.
• W2319344011 cites W1179790887 @default.
• W2319344011 cites W1498435409 @default.
• W2319344011 cites W1603573791 @default.
• W2319344011 cites W1887067355 @default.
• W2319344011 cites W1964093706 @default.
• W2319344011 cites W1970564212 @default.
• W2319344011 cites W1976010346 @default.
• W2319344011 cites W1978748886 @default.
• W2319344011 cites W1980365283 @default.
• W2319344011 cites W1985544918 @default.
• W2319344011 cites W1987916748 @default.
• W2319344011 cites W1989308631 @default.
• W2319344011 cites W1996510251 @default.
• W2319344011 cites W1996956643 @default.
• W2319344011 cites W2008326423 @default.
• W2319344011 cites W2014778415 @default.
• W2319344011 cites W2023235195 @default.
• W2319344011 cites W2028332032 @default.
• W2319344011 cites W2041525670 @default.
• W2319344011 cites W2050658165 @default.
• W2319344011 cites W2052186632 @default.
• W2319344011 cites W2061056490 @default.
• W2319344011 cites W2069088440 @default.
• W2319344011 cites W2075313898 @default.
• W2319344011 cites W2077668281 @default.
• W2319344011 cites W2082362498 @default.
• W2319344011 cites W2083310100 @default.
• W2319344011 cites W2087363103 @default.
• W2319344011 cites W2090105299 @default.
• W2319344011 cites W2090225270 @default.
• W2319344011 cites W2092432534 @default.
• W2319344011 cites W2098839264 @default.
• W2319344011 cites W2100252544 @default.
• W2319344011 cites W2103856324 @default.
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• W2319344011 cites W2118067546 @default.
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• W2319344011 cites W2140152000 @default.
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• W2319344011 cites W2140745627 @default.
• W2319344011 cites W2146199022 @default.
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• W2319344011 cites W2163022996 @default.
• W2319344011 cites W2166008303 @default.
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• W2319344011 doi "https://doi.org/10.1097/wco.0000000000000304" @default.
• W2319344011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4834991" @default.
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