FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319344479> ?p ?o ?g. }

• W2319344479 endingPage "120" @default.
• W2319344479 startingPage "114" @default.
• W2319344479 abstract "Alpha 1-antitrypsin (α1AT) deficiency disease is one of the more common hereditary disorders that affects the liver and lung. The liver disease of α1AT deficiency is generally thought to be caused by the accumulation of an abnormal α1AT protein in hepatocytes, whereas the lung disease is thought to be due to a relative lack of the normal protein in the circulation. Therefore, one possible approach to prevent and treat α1AT disease is to both inhibit the expression of the mutated α1AT gene, and to provide a means of synthesizing the normal protein. To do this, we designed specific hammerhead ribozymes that were capable of cleaving the α1AT mRNA at specific sites, and constructed a modified α1AT cDNA not susceptible to ribozyme cleavage. Ribozymes were effective in inhibiting α1AT expression in a human hepatoma cell line using a newly developed simian virus (SV40) vector system. In addition, the hepatoma cell line was stably transduced with a modified α1AT cDNA that was capable of producing wild-type α1AT protein, but was not cleaved by the ribozyme that decreased endogenous α1AT expression. These results suggest that ribozymes can be employed for the specific inhibition for an abnormal α1AT gene product, the first step in designing a gene therapy for the disease. The findings also suggest that the novel SV40-derived vector may represent a fundamental improvement in the gene therapeutic armarmentarium." @default.
• W2319344479 created "2016-06-24" @default.
• W2319344479 creator A5007716183 @default.
• W2319344479 creator A5026097438 @default.
• W2319344479 creator A5039703890 @default.
• W2319344479 creator A5050619824 @default.
• W2319344479 creator A5079168384 @default.
• W2319344479 creator A5089658377 @default.
• W2319344479 date "1999-01-01" @default.
• W2319344479 modified "2023-09-26" @default.
• W2319344479 title "A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line" @default.
• W2319344479 cites W106737342 @default.
• W2319344479 cites W1486018834 @default.
• W2319344479 cites W1516920673 @default.
• W2319344479 cites W1968820402 @default.
• W2319344479 cites W1968847695 @default.
• W2319344479 cites W1968960126 @default.
• W2319344479 cites W1981427241 @default.
• W2319344479 cites W1997261857 @default.
• W2319344479 cites W2015243129 @default.
• W2319344479 cites W2025560515 @default.
• W2319344479 cites W2036471649 @default.
• W2319344479 cites W2047629729 @default.
• W2319344479 cites W2047658890 @default.
• W2319344479 cites W2050992506 @default.
• W2319344479 cites W2055324838 @default.
• W2319344479 cites W2064071282 @default.
• W2319344479 cites W2070942587 @default.
• W2319344479 cites W2078321284 @default.
• W2319344479 cites W2087816015 @default.
• W2319344479 cites W2096577310 @default.
• W2319344479 cites W2106905907 @default.
• W2319344479 cites W2115066994 @default.
• W2319344479 cites W2149679794 @default.
• W2319344479 cites W2161340273 @default.
• W2319344479 cites W2164835084 @default.
• W2319344479 cites W2325223078 @default.
• W2319344479 cites W4294216491 @default.
• W2319344479 doi "https://doi.org/10.1038/sj.gt.3300793" @default.
• W2319344479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10341883" @default.
• W2319344479 hasPublicationYear "1999" @default.
• W2319344479 type Work @default.
• W2319344479 sameAs 2319344479 @default.
• W2319344479 citedByCount "48" @default.
• W2319344479 countsByYear W23193444792012 @default.
• W2319344479 countsByYear W23193444792013 @default.
• W2319344479 countsByYear W23193444792014 @default.
• W2319344479 countsByYear W23193444792015 @default.
• W2319344479 countsByYear W23193444792017 @default.
• W2319344479 countsByYear W23193444792018 @default.
• W2319344479 crossrefType "journal-article" @default.
• W2319344479 hasAuthorship W2319344479A5007716183 @default.
• W2319344479 hasAuthorship W2319344479A5026097438 @default.
• W2319344479 hasAuthorship W2319344479A5039703890 @default.
• W2319344479 hasAuthorship W2319344479A5050619824 @default.
• W2319344479 hasAuthorship W2319344479A5079168384 @default.
• W2319344479 hasAuthorship W2319344479A5089658377 @default.
• W2319344479 hasBestOaLocation W23193444791 @default.
• W2319344479 hasConcept C104317684 @default.
• W2319344479 hasConcept C105580179 @default.
• W2319344479 hasConcept C111599444 @default.
• W2319344479 hasConcept C150194340 @default.
• W2319344479 hasConcept C153911025 @default.
• W2319344479 hasConcept C187882448 @default.
• W2319344479 hasConcept C33161422 @default.
• W2319344479 hasConcept C40767141 @default.
• W2319344479 hasConcept C54009773 @default.
• W2319344479 hasConcept C54355233 @default.
• W2319344479 hasConcept C67705224 @default.
• W2319344479 hasConcept C76346623 @default.
• W2319344479 hasConcept C81885089 @default.
• W2319344479 hasConcept C86803240 @default.
• W2319344479 hasConceptScore W2319344479C104317684 @default.
• W2319344479 hasConceptScore W2319344479C105580179 @default.
• W2319344479 hasConceptScore W2319344479C111599444 @default.
• W2319344479 hasConceptScore W2319344479C150194340 @default.
• W2319344479 hasConceptScore W2319344479C153911025 @default.
• W2319344479 hasConceptScore W2319344479C187882448 @default.
• W2319344479 hasConceptScore W2319344479C33161422 @default.
• W2319344479 hasConceptScore W2319344479C40767141 @default.
• W2319344479 hasConceptScore W2319344479C54009773 @default.
• W2319344479 hasConceptScore W2319344479C54355233 @default.
• W2319344479 hasConceptScore W2319344479C67705224 @default.
• W2319344479 hasConceptScore W2319344479C76346623 @default.
• W2319344479 hasConceptScore W2319344479C81885089 @default.
• W2319344479 hasConceptScore W2319344479C86803240 @default.
• W2319344479 hasIssue "1" @default.
• W2319344479 hasLocation W23193444791 @default.
• W2319344479 hasLocation W23193444792 @default.
• W2319344479 hasOpenAccess W2319344479 @default.
• W2319344479 hasPrimaryLocation W23193444791 @default.
• W2319344479 hasRelatedWork W1946357342 @default.
• W2319344479 hasRelatedWork W2352258017 @default.
• W2319344479 hasRelatedWork W2364319975 @default.
• W2319344479 hasRelatedWork W2370293616 @default.
• W2319344479 hasRelatedWork W2376774677 @default.
• W2319344479 hasRelatedWork W2386240997 @default.
• W2319344479 hasRelatedWork W2401891876 @default.

• next