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- W2319472270 endingPage "57" @default.
- W2319472270 startingPage "57" @default.
- W2319472270 abstract "Diabetes mellitus is associated with cognitive deficits in humans and animals. These deficits are paralleled by neurophysiological and structural changes in brain. In diabetic animals, impairments of spatial learning, memory, and cognition occur in association with distinct changes in hippocampus, a key brain area for many forms of learning and memory and are particularly sensitive to changes in glucose homeostasis. However, the multifactorial pathogenesis of diabetic encephalopathy is not yet completely understood. Apoptosis plays a crucial role in diabetes-induce neuronal loss in hippocampus.The effects of diabetes on hippocampus and cognitive/behavioral dysfunctions in experimental models of diabetes are reviewed, with a focus on the negative impact on increased neuronal apoptosis and related cellular and molecular mechanisms.Of all articles that were assessed, most of the experimental studies clearly showed that diabetes causes neuronal apoptosis in hippocampus through multiple mechanisms, including oxidative stress, inhibition of caspases, disturbance in expression of apoptosis regulator genes, as well as deficits in mitochondrial function. The balance between pro-apoptotic and anti-apoptotic signaling may determine the neuronal apoptotic outcome in vitro and in vivo models of experimental diabetes.Dissecting out the mechanisms responsible for diabetes-related changes in the hippocampal cell apoptosis helps improve treatment of impaired cognitive and memory functions in diabetic individuals." @default.
- W2319472270 created "2016-06-24" @default.
- W2319472270 creator A5015936238 @default.
- W2319472270 creator A5018281679 @default.
- W2319472270 creator A5022135520 @default.
- W2319472270 creator A5031258848 @default.
- W2319472270 creator A5083159289 @default.
- W2319472270 date "2016-01-01" @default.
- W2319472270 modified "2023-09-30" @default.
- W2319472270 title "The effect of diabetes mellitus on apoptosis in hippocampus: Cellular and molecular aspects" @default.
- W2319472270 cites W131957466 @default.
- W2319472270 cites W1454820827 @default.
- W2319472270 cites W1492177644 @default.
- W2319472270 cites W1508167383 @default.
- W2319472270 cites W1558538004 @default.
- W2319472270 cites W1578833164 @default.
- W2319472270 cites W1705001022 @default.
- W2319472270 cites W1858411249 @default.
- W2319472270 cites W1933803332 @default.
- W2319472270 cites W1948207118 @default.
- W2319472270 cites W1967789041 @default.
- W2319472270 cites W1968000777 @default.
- W2319472270 cites W1968699748 @default.
- W2319472270 cites W1970665848 @default.
- W2319472270 cites W1974097121 @default.
- W2319472270 cites W1974588388 @default.
- W2319472270 cites W1976313368 @default.
- W2319472270 cites W1984214648 @default.
- W2319472270 cites W1984797840 @default.
- W2319472270 cites W1987329160 @default.
- W2319472270 cites W1988991404 @default.
- W2319472270 cites W1995941794 @default.
- W2319472270 cites W2007556598 @default.
- W2319472270 cites W2008757142 @default.
- W2319472270 cites W2010222033 @default.
- W2319472270 cites W2019561288 @default.
- W2319472270 cites W2019724009 @default.
- W2319472270 cites W2035069368 @default.
- W2319472270 cites W2036284058 @default.
- W2319472270 cites W2042141743 @default.
- W2319472270 cites W2043503204 @default.
- W2319472270 cites W2044150433 @default.
- W2319472270 cites W2047662727 @default.
- W2319472270 cites W2049207423 @default.
- W2319472270 cites W2050490622 @default.
- W2319472270 cites W2050970964 @default.
- W2319472270 cites W2051823419 @default.
- W2319472270 cites W2053557703 @default.
- W2319472270 cites W2056027814 @default.
- W2319472270 cites W2056456156 @default.
- W2319472270 cites W2059277649 @default.
- W2319472270 cites W2066536370 @default.
- W2319472270 cites W2068608676 @default.
- W2319472270 cites W2072062185 @default.
- W2319472270 cites W2073373063 @default.
- W2319472270 cites W2073474008 @default.
- W2319472270 cites W2073784844 @default.
- W2319472270 cites W2075211485 @default.
- W2319472270 cites W2076752309 @default.
- W2319472270 cites W2084258035 @default.
- W2319472270 cites W2089550153 @default.
- W2319472270 cites W2090573853 @default.
- W2319472270 cites W2097815597 @default.
- W2319472270 cites W2099408652 @default.
- W2319472270 cites W2119177839 @default.
- W2319472270 cites W2120002749 @default.
- W2319472270 cites W2120447295 @default.
- W2319472270 cites W2124095103 @default.
- W2319472270 cites W2125741047 @default.
- W2319472270 cites W2134723636 @default.
- W2319472270 cites W2136635797 @default.
- W2319472270 cites W2142644414 @default.
- W2319472270 cites W2143417663 @default.
- W2319472270 cites W2146998182 @default.
- W2319472270 cites W2152582537 @default.
- W2319472270 cites W2153169128 @default.
- W2319472270 cites W2153948861 @default.
- W2319472270 cites W2163097079 @default.
- W2319472270 cites W2164307469 @default.
- W2319472270 cites W2165563030 @default.
- W2319472270 cites W2167415409 @default.
- W2319472270 cites W2167543749 @default.
- W2319472270 cites W2169584252 @default.
- W2319472270 cites W2169806530 @default.
- W2319472270 cites W2171242179 @default.
- W2319472270 cites W2274505782 @default.
- W2319472270 cites W2286763909 @default.
- W2319472270 cites W22925787 @default.
- W2319472270 cites W2325449366 @default.
- W2319472270 cites W2333843090 @default.
- W2319472270 cites W2353198346 @default.
- W2319472270 cites W2383425915 @default.
- W2319472270 cites W2404134687 @default.
- W2319472270 cites W2404718644 @default.
- W2319472270 cites W2413154032 @default.
- W2319472270 cites W2427974502 @default.
- W2319472270 cites W2464352486 @default.
- W2319472270 cites W563315964 @default.