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- W2319750241 abstract "The present study was designed to elucidate the effect of topical cooling for preventing liver injury during extended hepatectomy with hepatic vascular exclusion. Adult mongrel dogs (9.5-17.5kg, n=19) were used in this experimental study. Seventy-five % of the liver was resected in each dog. The animals were divided into three groups. : The control group without inflow clamp at hepatectomy, the clamp group with hepatic inflow clamp for 60 minutes at hepatectomy, and the cooling group with topical cooling using ice slush during inflow clamp (core temperature of the liver ; 13.3 ± 0.3°C). GPT, GOT, LDH as the marker of hepatocyte injury and purine nucleoside phosphorylase (PNP) as the marker of non-hepatocyte injury were measured. Results were as follows : The seven-day survival of the animals in the cooling group was better than that in the clamp group. The serum levels of GPT, GOT, LDH showed no significant differences between the clamp and the cooling groups. PNP activity of the cooling group was significantly lower (P<0.01) than that of the clamp group immediately after hepatectomy. These findings suggest that topical cooling of the liver prevents non-hepatocyte injury at the time of extended hepatectomy with hepatic vascular exclusion." @default.
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- W2319750241 date "1994-01-01" @default.
- W2319750241 modified "2023-10-02" @default.
- W2319750241 title "THE EFFECT OF TOPICAL COOLING IN EXTENDED HEPATECTOMY WITH HEPATIC VASCULAR EXCLUSION OF THE CANINE LIVER" @default.
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- W2319750241 doi "https://doi.org/10.2974/kmj1951.44.563" @default.
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