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• W2319784705 endingPage "769" @default.
• W2319784705 startingPage "752" @default.
• W2319784705 abstract "Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates--tau oligomers--are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions." @default.
• W2319784705 created "2016-06-24" @default.
• W2319784705 creator A5019084646 @default.
• W2319784705 creator A5072009686 @default.
• W2319784705 creator A5075993949 @default.
• W2319784705 date "2014-08-08" @default.
• W2319784705 modified "2023-10-14" @default.
• W2319784705 title "Advances in Therapeutics for Neurodegenerative Tauopathies: Moving toward the Specific Targeting of the Most Toxic Tau Species" @default.
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