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• W2319805658 abstract "Event Abstract Back to Event Naproxen alleviates anaphylactoid reactions to N-acetylcysteine in healthy volunteers Mohammadreza -. Sattari1, 2* and Siminozar Mashayekhi3 1 Tabriz University of Medical Sciences, Pharmacology and Toxicology, Iran 2 Neurosciences Research Centre, Iran 3 Tabriz University of Medical Sciences, Clinical Pharmacy, Iran A relationship has been demonstrated between a low serum paracetamol at the time of treatment and the development of anaphilactoid adverse reactions to N-acetylcysteine (NAC). This finding was interpreted by the authors that paracetamol itself might actually offer some protection against the development of adverse effects to NAC. Naproxen inhibits the production of thromboxane by 95% and platelet aggregation by 88%. To inhibit the cyclo-oxygenase activity before starting an NAC trial on healthy volunteers, at least 7g paracetamol would be need. Since administration of this dose to healthy volunteers was not feasible, an alternative option was to use a NSAID instead of paracetamol before the trial. Therefore, a cyclo-oxygenase inhibitor (naproxen) for was used. Ten healthy male volunteers, age between 23-40 (median 32) and weight between 63-87kg (median 78.5) were recruited from the general population after fully informed and written consent and after ethical approval. Each volunteer was asked to participate on two separate occasions: pre-treatment with naproxen prior to infusion of NAC using the recommended UK regimen and without naproxen pre-treatment. Data were analysed by using Excel, Prism, and WinNonlin software packages as appropriate. Plasma histamine concentration was determined during intravenous administration by an ELISA method. A paired t-test showed that plasma histamine was significantly higher at 10 and 15min in the control phase compared with the naproxen pre-treatment phase (P<0.05). Histamine release may not only mechanism of adverse events associated with NAC but also release of some other factors e.g. prostaglandines or tromboxanes could be involved. Keywords: Naproxen, N-acetylcysteine (NAC), paracetamol, Acetaminophen, cyclo-oxygenase Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Sattari M- and Mashayekhi S (2013). Naproxen alleviates anaphylactoid reactions to N-acetylcysteine in healthy volunteers. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00694 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Mohammadreza - Sattari, Tabriz University of Medical Sciences, Pharmacology and Toxicology, Tabriz, Iran, mrgsuk@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mohammadreza - Sattari Siminozar Mashayekhi Google Mohammadreza - Sattari Siminozar Mashayekhi Google Scholar Mohammadreza - Sattari Siminozar Mashayekhi PubMed Mohammadreza - Sattari Siminozar Mashayekhi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2319805658 title "Naproxen alleviates anaphylactoid reactions to N-acetylcysteine in healthy volunteers" @default.
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