Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319850132> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2319850132 endingPage "1096" @default.
- W2319850132 startingPage "1096.1" @default.
- W2319850132 abstract "<h3>Background</h3> Familial Mediterranean fever (FMF) is the most frequent hereditary autoinflammatory disease, characterized by recurrent self-limited attacks of fever and polyserositis. The development of renal amyloidosis type AA is the most devastating manifestation of the disease. Apart from major target organs as renal, cardiovascular, respiratory and gastrointestinal system, endocrine organs can also be involved. Yet, it is unclear how FMF affects thyroid function in patients that are not complicated with amyloidosis. <h3>Objectives</h3> The aim of this study was to evaluate the thyroid function in children with FMF that are not complicated with amyloidosis. <h3>Methods</h3> A cross-sectional study was carried out in pediatric rheumatology outpatient clinics. The medical records of patients with FMF were reviewed. Demographic characteristics, disease duration, mutation analysis, clinical findings, free T3, free T4, TSH were all noted at attack free periods. <h3>Results</h3> A total of 82 children, 42 girls (51.2%), with a mean age of 7.76±3.76 years at diagnosis and disease duration 22.31±24.42months, were included. Twenty one (25.6%) patients were found to have parental consanguinity and 31 (37.8%) patients had family history of FMF. Twelve (14.6%) patients were homozygous, 25 (30.5%) patients were compound heterozygous and 34 (41.5%) patients were heterozygous for MEFV gene. Eleven (13.4%) patients had complex allele mutations (≥3 mutations). Colchicine treatment was started in all patients. The dosage of colchicine needed to control the disease symptoms was 0.95±0.31 mg/day. The mean serum free T3, free T4 and TSH levels of patients were 3.96±0.54 pg/ml, 1.15±0.15 ng/ml, and 2.53±2.25 micU/ml, respectively. Hypothyroidism requiring levothyroxine treatment was found in 2 patients (2.43%) at the time of the study and one patient was found to have subclinical hypothyroidism. <h3>Conclusions</h3> Although an association of hypothyroidsim and FMF has been reported before we did not find an increase prevalance of thyroid function abnormalities in children with FMF who are not complicated with amyloidosis. Our results suggest that thyroid function tests don9t need to be screened routinely in FMF patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5111" @default.
- W2319850132 created "2016-06-24" @default.
- W2319850132 creator A5003082447 @default.
- W2319850132 creator A5003646475 @default.
- W2319850132 creator A5006472864 @default.
- W2319850132 creator A5010757427 @default.
- W2319850132 creator A5072356649 @default.
- W2319850132 creator A5081687415 @default.
- W2319850132 date "2014-06-01" @default.
- W2319850132 modified "2023-10-01" @default.
- W2319850132 title "AB0892 Evaluation of Thyroid Function in Children with Familial Mediterranean Fever" @default.
- W2319850132 doi "https://doi.org/10.1136/annrheumdis-2014-eular.5111" @default.
- W2319850132 hasPublicationYear "2014" @default.
- W2319850132 type Work @default.
- W2319850132 sameAs 2319850132 @default.
- W2319850132 citedByCount "1" @default.
- W2319850132 countsByYear W23198501322020 @default.
- W2319850132 crossrefType "journal-article" @default.
- W2319850132 hasAuthorship W2319850132A5003082447 @default.
- W2319850132 hasAuthorship W2319850132A5003646475 @default.
- W2319850132 hasAuthorship W2319850132A5006472864 @default.
- W2319850132 hasAuthorship W2319850132A5010757427 @default.
- W2319850132 hasAuthorship W2319850132A5072356649 @default.
- W2319850132 hasAuthorship W2319850132A5081687415 @default.
- W2319850132 hasConcept C104317684 @default.
- W2319850132 hasConcept C12125453 @default.
- W2319850132 hasConcept C126322002 @default.
- W2319850132 hasConcept C180754005 @default.
- W2319850132 hasConcept C185592680 @default.
- W2319850132 hasConcept C187212893 @default.
- W2319850132 hasConcept C198451711 @default.
- W2319850132 hasConcept C2779134260 @default.
- W2319850132 hasConcept C2779537928 @default.
- W2319850132 hasConcept C2779923321 @default.
- W2319850132 hasConcept C2779951007 @default.
- W2319850132 hasConcept C2781145326 @default.
- W2319850132 hasConcept C2993291352 @default.
- W2319850132 hasConcept C2994225774 @default.
- W2319850132 hasConcept C3020110884 @default.
- W2319850132 hasConcept C501734568 @default.
- W2319850132 hasConcept C526584372 @default.
- W2319850132 hasConcept C55493867 @default.
- W2319850132 hasConcept C71924100 @default.
- W2319850132 hasConcept C90924648 @default.
- W2319850132 hasConceptScore W2319850132C104317684 @default.
- W2319850132 hasConceptScore W2319850132C12125453 @default.
- W2319850132 hasConceptScore W2319850132C126322002 @default.
- W2319850132 hasConceptScore W2319850132C180754005 @default.
- W2319850132 hasConceptScore W2319850132C185592680 @default.
- W2319850132 hasConceptScore W2319850132C187212893 @default.
- W2319850132 hasConceptScore W2319850132C198451711 @default.
- W2319850132 hasConceptScore W2319850132C2779134260 @default.
- W2319850132 hasConceptScore W2319850132C2779537928 @default.
- W2319850132 hasConceptScore W2319850132C2779923321 @default.
- W2319850132 hasConceptScore W2319850132C2779951007 @default.
- W2319850132 hasConceptScore W2319850132C2781145326 @default.
- W2319850132 hasConceptScore W2319850132C2993291352 @default.
- W2319850132 hasConceptScore W2319850132C2994225774 @default.
- W2319850132 hasConceptScore W2319850132C3020110884 @default.
- W2319850132 hasConceptScore W2319850132C501734568 @default.
- W2319850132 hasConceptScore W2319850132C526584372 @default.
- W2319850132 hasConceptScore W2319850132C55493867 @default.
- W2319850132 hasConceptScore W2319850132C71924100 @default.
- W2319850132 hasConceptScore W2319850132C90924648 @default.
- W2319850132 hasIssue "Suppl 2" @default.
- W2319850132 hasLocation W23198501321 @default.
- W2319850132 hasOpenAccess W2319850132 @default.
- W2319850132 hasPrimaryLocation W23198501321 @default.
- W2319850132 hasRelatedWork W1993407279 @default.
- W2319850132 hasRelatedWork W1994770266 @default.
- W2319850132 hasRelatedWork W2035985228 @default.
- W2319850132 hasRelatedWork W2123254283 @default.
- W2319850132 hasRelatedWork W2319850132 @default.
- W2319850132 hasRelatedWork W2326746311 @default.
- W2319850132 hasRelatedWork W2406139671 @default.
- W2319850132 hasRelatedWork W2525549620 @default.
- W2319850132 hasRelatedWork W279500359 @default.
- W2319850132 hasRelatedWork W2104509169 @default.
- W2319850132 hasVolume "73" @default.
- W2319850132 isParatext "false" @default.
- W2319850132 isRetracted "false" @default.
- W2319850132 magId "2319850132" @default.
- W2319850132 workType "article" @default.