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- W2319853392 abstract "Scope Tumor metastasis greatly contributes to the mortality of prostate cancer. The glucosinolate‐derived phenethyl isothiocyanate (PEITC) has been widely documented to reduce the risk of prostate cancer by modulating multiple biologically relevant processes. Emerging evidence suggests that PEITC may exert its anti‐cancer effects through epigenetic mechanisms including microRNAs. Altered levels of miRNA have been linked to tumor malignancy due to their capacity to regulate functional gene expression in carcinogenesis. Here, we assessed the effects of PEITC on miRNA expression which is related to PCa cell invasiveness. Methods and results Utilizing oligonucleotide microarray first identified the most affected miRNAs in LNCaP cells after PEITC treatment. Several top altered miRNAs were further validated using quantitative PCR. Interestingly, overexpression of miR‐194 suppressed PC3 cell invasion in matrigel‐coated Transwell chambers. Bone morphogenetic protein 1 (BMP1) was shown to be a direct target of miR‐194. Downregulation of BMP1 by miR‐194 or PEITC led to decreased expression of key oncogenic matrix metalloproteinases, MMP2 and MMP9. This in turn resulted in the suppression of tumor invasion. Conclusion Our results indicate that miR‐194 downregulates the expression of oncogenic MMP2 and MMP9 by targeting BMP1, which suggests a potential new mechanistic target by which PEITC suppresses prostate cancer cell invasiveness." @default.
- W2319853392 created "2016-06-24" @default.
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- W2319853392 date "2016-05-17" @default.
- W2319853392 modified "2023-09-25" @default.
- W2319853392 title "Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194" @default.
- W2319853392 cites W1520425169 @default.
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- W2319853392 cites W1838766486 @default.
- W2319853392 cites W1951894216 @default.
- W2319853392 cites W1964937451 @default.
- W2319853392 cites W1967103142 @default.
- W2319853392 cites W1968008181 @default.
- W2319853392 cites W1968172616 @default.
- W2319853392 cites W1984254481 @default.
- W2319853392 cites W2008555392 @default.
- W2319853392 cites W2016046687 @default.
- W2319853392 cites W2022579819 @default.
- W2319853392 cites W2022906598 @default.
- W2319853392 cites W2028798336 @default.
- W2319853392 cites W2029127250 @default.
- W2319853392 cites W2029300527 @default.
- W2319853392 cites W2033681249 @default.
- W2319853392 cites W2037257887 @default.
- W2319853392 cites W2041796644 @default.
- W2319853392 cites W2043704189 @default.
- W2319853392 cites W2048603557 @default.
- W2319853392 cites W2050850788 @default.
- W2319853392 cites W2050869737 @default.
- W2319853392 cites W2051227958 @default.
- W2319853392 cites W2054020882 @default.
- W2319853392 cites W2059073003 @default.
- W2319853392 cites W2060326505 @default.
- W2319853392 cites W2060650901 @default.
- W2319853392 cites W2061801920 @default.
- W2319853392 cites W2062290101 @default.
- W2319853392 cites W2067012955 @default.
- W2319853392 cites W2069928663 @default.
- W2319853392 cites W2072751712 @default.
- W2319853392 cites W2076060004 @default.
- W2319853392 cites W2078476100 @default.
- W2319853392 cites W2081391850 @default.
- W2319853392 cites W2084169171 @default.
- W2319853392 cites W2086977605 @default.
- W2319853392 cites W2090017296 @default.
- W2319853392 cites W2094253263 @default.
- W2319853392 cites W2096435311 @default.
- W2319853392 cites W2098139456 @default.
- W2319853392 cites W2101875154 @default.
- W2319853392 cites W2103130607 @default.
- W2319853392 cites W2108527180 @default.
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- W2319853392 cites W2113754522 @default.
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- W2319853392 cites W2136700586 @default.
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- W2319853392 cites W2150203365 @default.
- W2319853392 cites W2152970611 @default.
- W2319853392 cites W2153840778 @default.
- W2319853392 cites W2156334030 @default.
- W2319853392 cites W2160968516 @default.
- W2319853392 cites W2163229196 @default.
- W2319853392 cites W2163785113 @default.
- W2319853392 cites W2166531817 @default.
- W2319853392 cites W2168230240 @default.
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- W2319853392 doi "https://doi.org/10.1002/mnfr.201500918" @default.
- W2319853392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5495185" @default.
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