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- W2319865685 abstract "Systemic administration of endotoxin which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study, we studied comprehensively the characteristics of adrenal gland dysregulation, including inflammation, leukocyte infiltration and cell death in the adrenal glands in the course of LPS-induced systemic inflammation in mice. LPS strongly enhanced expression of many proinflammatory cytokines, chemokines and adhesion molecules, which resulted in rapid recruitment of leukocytes into the adrenal gland. Furthermore, LPS-mediated inflammation was associated with increased apoptosis of adrenocortical and chromaffin cells. Our results performed on mice, suggest that LPS-induced adrenal gland inflammation and cell death can be potentially involved in the adrenal gland dysfunction in patients with sepsis" @default.
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- W2319865685 date "2013-03-07" @default.
- W2319865685 modified "2023-09-25" @default.
- W2319865685 title "Characterization of the LPS-induced inflammation of the adrenal gland in mice" @default.
- W2319865685 doi "https://doi.org/10.1055/s-0033-1336760" @default.
- W2319865685 hasPublicationYear "2013" @default.
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