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- W2319903290 abstract "Pregnancy with type 1 diabetes is considered to have a high incidence of pre-eclampsia (PET), but these women often have hypertension or proteinuria at <20 weeks gestation confusing the diagnosis. The DAPIT study randomised 762 women with type 1 diabetes to vitamin C and E supplementation, to investigate if this reduced the incidence of PET. As no significant effect was found both groups were combined allowing analysis of hypertensive disorders in a large cohort. Before pregnancy, previous hypertension was noted in 25% of women who developed PET, 13% of women who developed gestational hypertension (GHT) and 10% who had neither (p <0.001). By 20 weeks 32% of women had hypertension, proteinuria or both and 29% were subsequently classified as having PET in contrast to only 12% who had no problem <20 weeks (p <0.0001). However, of those who were classified as having PET, 56% had evidence of hypertensive or renal impairment <20 weeks compared to 24% who had no subsequent hypertensive problem (p <0.0001). While liver enzymes and serum urate were significantly elevated in the PET group the results were similar whether or not there was a problem <20 weeks. However thrombocytopenia occurred more in the PET group who only had a problem >20 weeks. Birthweight <5<sup>th</sup> and <90<sup>th</sup> centile was significantly greater in the PET group, but significantly more in those with a problem<20 weeks. In conclusion not all diabetic women classified as having PET appear to have the condition but further markers are required to differentiate." @default.
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- W2319903290 date "2012-04-01" @default.
- W2319903290 modified "2023-09-26" @default.
- W2319903290 title "Is pre-eclampsia really increased in women with type 1 diabetes?" @default.
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- W2319903290 doi "https://doi.org/10.1136/fetalneonatal-2012-301809.157" @default.
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