Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319908006> ?p ?o ?g. }
- W2319908006 abstract "Many factors contribute to the pathogenesis of autoimmune diabetes. Targets for treating this debilitating disease will become more apparent by understanding the nature of immune activation. This review examines the possibility of targeting costimulation and discusses the molecules found on the T cell and the antigen-presenting cell (APC) that participate in T-cell activation. The B7-1/B7-2:CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4) pathway has been shown to be crucial in regulating T-cell activation and tolerance. Novel members of the B7-CD28 superfamily have recently been discovered, and they appear to be particularly important for regulating the responses of previously activated T cells. Superimposition of inhibitory signals, such as those delivered by CTLA-4 and the programmed death (PD)-1-PD-1 ligand (PD-L1) pathway, leads to a complex network of positive and negative costimulatory signals, the integration of which modulates immune responses. Furthermore, expression of the B7 homolog B7-H4 on cells in peripheral tissues indicates new mechanisms for regulating T-cell responses. This review focuses on our current understanding of the members of the B7:CD28 superfamily and discusses their therapeutic potential in autoimmune diabetes." @default.
- W2319908006 created "2016-06-24" @default.
- W2319908006 creator A5006597580 @default.
- W2319908006 creator A5046141743 @default.
- W2319908006 creator A5065048439 @default.
- W2319908006 creator A5073254270 @default.
- W2319908006 date "2011-01-01" @default.
- W2319908006 modified "2023-09-27" @default.
- W2319908006 title "The Role of T-Cell Costimulatory Pathways in Regulation of Autoimmune Diabetes" @default.
- W2319908006 cites W1487911472 @default.
- W2319908006 cites W1490870966 @default.
- W2319908006 cites W1513609509 @default.
- W2319908006 cites W1516026495 @default.
- W2319908006 cites W1516446271 @default.
- W2319908006 cites W1538902372 @default.
- W2319908006 cites W1542262758 @default.
- W2319908006 cites W1562369175 @default.
- W2319908006 cites W1564765245 @default.
- W2319908006 cites W1581904411 @default.
- W2319908006 cites W1590451328 @default.
- W2319908006 cites W1606112045 @default.
- W2319908006 cites W1613769575 @default.
- W2319908006 cites W1661441964 @default.
- W2319908006 cites W1738685314 @default.
- W2319908006 cites W1752045965 @default.
- W2319908006 cites W1893566975 @default.
- W2319908006 cites W1966519046 @default.
- W2319908006 cites W1972640898 @default.
- W2319908006 cites W1985106225 @default.
- W2319908006 cites W1986954791 @default.
- W2319908006 cites W1988257501 @default.
- W2319908006 cites W1992184534 @default.
- W2319908006 cites W1994688157 @default.
- W2319908006 cites W1994969460 @default.
- W2319908006 cites W1995181168 @default.
- W2319908006 cites W1997534998 @default.
- W2319908006 cites W1999843687 @default.
- W2319908006 cites W2000049562 @default.
- W2319908006 cites W2002876778 @default.
- W2319908006 cites W2009040933 @default.
- W2319908006 cites W2010660594 @default.
- W2319908006 cites W2029059014 @default.
- W2319908006 cites W2029855686 @default.
- W2319908006 cites W2037347344 @default.
- W2319908006 cites W2040572245 @default.
- W2319908006 cites W2041347201 @default.
- W2319908006 cites W2045932062 @default.
- W2319908006 cites W2048073154 @default.
- W2319908006 cites W2052077392 @default.
- W2319908006 cites W2055264495 @default.
- W2319908006 cites W2056209646 @default.
- W2319908006 cites W2056535502 @default.
- W2319908006 cites W2059557874 @default.
- W2319908006 cites W2061234870 @default.
- W2319908006 cites W2061434857 @default.
- W2319908006 cites W2062451762 @default.
- W2319908006 cites W2064964439 @default.
- W2319908006 cites W2068522718 @default.
- W2319908006 cites W2068639447 @default.
- W2319908006 cites W2069539210 @default.
- W2319908006 cites W2073871857 @default.
- W2319908006 cites W2075804595 @default.
- W2319908006 cites W2075819066 @default.
- W2319908006 cites W2076722399 @default.
- W2319908006 cites W2085604895 @default.
- W2319908006 cites W2087013294 @default.
- W2319908006 cites W2087757222 @default.
- W2319908006 cites W2091926760 @default.
- W2319908006 cites W2093963507 @default.
- W2319908006 cites W2100992652 @default.
- W2319908006 cites W2101230909 @default.
- W2319908006 cites W2101439769 @default.
- W2319908006 cites W2103137174 @default.
- W2319908006 cites W2107752337 @default.
- W2319908006 cites W2108933323 @default.
- W2319908006 cites W2112854542 @default.
- W2319908006 cites W2114799675 @default.
- W2319908006 cites W2114917841 @default.
- W2319908006 cites W2118471749 @default.
- W2319908006 cites W2121498145 @default.
- W2319908006 cites W2121934915 @default.
- W2319908006 cites W2130822830 @default.
- W2319908006 cites W2131950300 @default.
- W2319908006 cites W2133771102 @default.
- W2319908006 cites W2134523831 @default.
- W2319908006 cites W2136129817 @default.
- W2319908006 cites W2138132552 @default.
- W2319908006 cites W2139191751 @default.
- W2319908006 cites W2140710564 @default.
- W2319908006 cites W2143050297 @default.
- W2319908006 cites W2145871366 @default.
- W2319908006 cites W2147132132 @default.
- W2319908006 cites W2150430216 @default.
- W2319908006 cites W2158174447 @default.
- W2319908006 cites W2158840473 @default.
- W2319908006 cites W2162423605 @default.
- W2319908006 cites W2162675860 @default.
- W2319908006 cites W2164079212 @default.
- W2319908006 cites W2164903177 @default.
- W2319908006 cites W2169593537 @default.