FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319933663> ?p ?o ?g. }

• W2319933663 endingPage "996" @default.
• W2319933663 startingPage "989" @default.
• W2319933663 abstract "Background Transplant arteriosclerosis is a major cause of late intestinal allograft dysfunction. However, little is known about the immunologic and molecular mechanisms underlying it, and no effective treatment is available. This study aimed to investigate the role of sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) in transplant arteriosclerosis and find out whether fish oil (FO) attenuates allograft arteriosclerosis through S1P signaling. Methods A rat model with orthotopic intestinal transplantation was conducted in this study. Animals received daily FO supplementation after intestinal transplant. The allogeneic recipients by phosphate-buffered saline or corn oil treatment served as controls. The allograft arteriosclerosis was characterized, and the expression of SPHK1 and S1P receptors (S1P1, S1P2, and S1P3) was determined on day 190 posttransplant. Results The allogeneic controls presented transplant vasculopathy in mesenteric vessels, including intimal thickening, fibrosis, and leukocyte infiltration. The transplant arteriosclerosis was markedly reduced in FO-fed animals. The pression of SPHK1 and its activity were significantly augmented, and the expression of S1P1 and S1P3 messenger RNA was up-regulated in the allogeneic controls. FO supplementation suppressed the activation of SPHK1 and led to a decrease in the expression of S1P1 and S1P3 in these tissues in transplant arteriosclerosis. Conclusions These results demonstrate that the activation of SPHK1/S1P signaling plays a possible role in the pathogenesis of transplant arteriosclerosis. The reduction of allograft arteriosclerosis by FO may be associated with down-regulation of SPHK1/S1P signaling. Understanding the role of FO for SPHK1/S1P may help us to identify considerable therapeutic targets for transplant arteriosclerosis." @default.
• W2319933663 created "2016-06-24" @default.
• W2319933663 creator A5013860112 @default.
• W2319933663 creator A5031810848 @default.
• W2319933663 creator A5039837606 @default.
• W2319933663 creator A5062400152 @default.
• W2319933663 creator A5066252438 @default.
• W2319933663 creator A5086242915 @default.
• W2319933663 date "2012-05-27" @default.
• W2319933663 modified "2023-09-22" @default.
• W2319933663 title "The Reduction of Allograft Arteriosclerosis in Intestinal Transplant Is Associated With Sphingosine Kinase 1/Sphingosine-1-Phosphate Signaling After Fish Oil Treatment" @default.
• W2319933663 cites W1967802627 @default.
• W2319933663 cites W1968684759 @default.
• W2319933663 cites W1970447847 @default.
• W2319933663 cites W1973573934 @default.
• W2319933663 cites W1984621512 @default.
• W2319933663 cites W1991558659 @default.
• W2319933663 cites W1994977028 @default.
• W2319933663 cites W2002301651 @default.
• W2319933663 cites W2005071794 @default.
• W2319933663 cites W2008297143 @default.
• W2319933663 cites W2010090839 @default.
• W2319933663 cites W2013830689 @default.
• W2319933663 cites W2015645172 @default.
• W2319933663 cites W2021525739 @default.
• W2319933663 cites W2022770236 @default.
• W2319933663 cites W2027860233 @default.
• W2319933663 cites W2029911522 @default.
• W2319933663 cites W2035881418 @default.
• W2319933663 cites W2050640165 @default.
• W2319933663 cites W2052745477 @default.
• W2319933663 cites W2059611674 @default.
• W2319933663 cites W2068040688 @default.
• W2319933663 cites W2075737829 @default.
• W2319933663 cites W2075794294 @default.
• W2319933663 cites W2078509787 @default.
• W2319933663 cites W2096776589 @default.
• W2319933663 cites W2097302710 @default.
• W2319933663 cites W2108433399 @default.
• W2319933663 cites W2115289915 @default.
• W2319933663 cites W2125788704 @default.
• W2319933663 cites W2127985765 @default.
• W2319933663 cites W2130902918 @default.
• W2319933663 cites W2138940299 @default.
• W2319933663 cites W2162523489 @default.
• W2319933663 cites W2165597224 @default.
• W2319933663 cites W2167630574 @default.
• W2319933663 cites W2408169250 @default.
• W2319933663 doi "https://doi.org/10.1097/tp.0b013e31824d709d" @default.
• W2319933663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22466786" @default.
• W2319933663 hasPublicationYear "2012" @default.
• W2319933663 type Work @default.
• W2319933663 sameAs 2319933663 @default.
• W2319933663 citedByCount "4" @default.
• W2319933663 countsByYear W23199336632018 @default.
• W2319933663 countsByYear W23199336632020 @default.
• W2319933663 crossrefType "journal-article" @default.
• W2319933663 hasAuthorship W2319933663A5013860112 @default.
• W2319933663 hasAuthorship W2319933663A5031810848 @default.
• W2319933663 hasAuthorship W2319933663A5039837606 @default.
• W2319933663 hasAuthorship W2319933663A5062400152 @default.
• W2319933663 hasAuthorship W2319933663A5066252438 @default.
• W2319933663 hasAuthorship W2319933663A5086242915 @default.
• W2319933663 hasBestOaLocation W23199336631 @default.
• W2319933663 hasConcept C126322002 @default.
• W2319933663 hasConcept C134018914 @default.
• W2319933663 hasConcept C142724271 @default.
• W2319933663 hasConcept C170493617 @default.
• W2319933663 hasConcept C203014093 @default.
• W2319933663 hasConcept C2776393769 @default.
• W2319933663 hasConcept C2776596873 @default.
• W2319933663 hasConcept C2777550365 @default.
• W2319933663 hasConcept C2778703144 @default.
• W2319933663 hasConcept C2911091166 @default.
• W2319933663 hasConcept C61705674 @default.
• W2319933663 hasConcept C71924100 @default.
• W2319933663 hasConcept C86803240 @default.
• W2319933663 hasConcept C95444343 @default.
• W2319933663 hasConceptScore W2319933663C126322002 @default.
• W2319933663 hasConceptScore W2319933663C134018914 @default.
• W2319933663 hasConceptScore W2319933663C142724271 @default.
• W2319933663 hasConceptScore W2319933663C170493617 @default.
• W2319933663 hasConceptScore W2319933663C203014093 @default.
• W2319933663 hasConceptScore W2319933663C2776393769 @default.
• W2319933663 hasConceptScore W2319933663C2776596873 @default.
• W2319933663 hasConceptScore W2319933663C2777550365 @default.
• W2319933663 hasConceptScore W2319933663C2778703144 @default.
• W2319933663 hasConceptScore W2319933663C2911091166 @default.
• W2319933663 hasConceptScore W2319933663C61705674 @default.
• W2319933663 hasConceptScore W2319933663C71924100 @default.
• W2319933663 hasConceptScore W2319933663C86803240 @default.
• W2319933663 hasConceptScore W2319933663C95444343 @default.
• W2319933663 hasIssue "10" @default.
• W2319933663 hasLocation W23199336631 @default.
• W2319933663 hasLocation W23199336632 @default.
• W2319933663 hasOpenAccess W2319933663 @default.
• W2319933663 hasPrimaryLocation W23199336631 @default.
• W2319933663 hasRelatedWork W1991575691 @default.

• next