FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319938861> ?p ?o ?g. }

• W2319938861 endingPage "12713" @default.
• W2319938861 startingPage "12706" @default.
• W2319938861 abstract "In this paper, we propose a new way of thinking about molecular self-organization of the antibiotic amphotericin B (AmB) by examination of its N-iodoacetyl derivative (AmB-I). This choice was dictated by the simplicity of AmB-I crystallization as compared to pure AmB. The studies focus on spectroscopic investigations of the monocrystal and the amorphous state of AmB-I. The results of vibrational, FTIR, and Raman spectroscopy show differences between the crystalline and amorphous forms, in particular for bands attributed to C═O (1700–1730 cm–1) and C—C—H groups, as well as C═C—C (ca. 1010 cm–1) stretching vibrations. The process of crystallization is identified by strong differences in the intensities and locations of these characteristic bands. For the AmB-I crystals, the carbonyl band is shifted toward lower frequencies as a result of intensified hydrogen bonding in the crystalline form. Detailed analysis indicates that bands in the region characteristic for the C═C—C bending distortion in the chromophore are particularly intense for AmB-I in the crystalline form as compared to the intensity of this band in the amorphous state. These findings are corroborated by the results of fluorescence spectroscopy. We observe a much faster decay of the emission for the AmB-I monocrystal as compared to the DMSO solution of AmB-I. Interestingly, the fluorescence decay in the amorphous form requires three decay times for simulating the observed behavior; two of these decay constants are sufficient for estimating the decay measured for the AmB-I crystals. The proof of the molecular organization of AmB-I molecules is obtained from polarization-resolved fluorescence spectroscopy on a single AmB-I crystal. Strong anisotropy of the emission intensity correlates with the axes of the crystal, providing insight into actual alignment of the molecules in the AmB-I crystals. These findings related to molecular organization in AmB-I crystals are crucial for understanding toxicity mechanisms of the clinically used drug, amphotericin B." @default.
• W2319938861 created "2016-06-24" @default.
• W2319938861 creator A5034089618 @default.
• W2319938861 creator A5067800648 @default.
• W2319938861 creator A5069492269 @default.
• W2319938861 creator A5087559023 @default.
• W2319938861 creator A5089840521 @default.
• W2319938861 date "2012-10-15" @default.
• W2319938861 modified "2023-10-17" @default.
• W2319938861 title "Spectroscopic Evidence for Self-Organization of <i>N</i>-Iodoacetylamphotericin B in Crystalline and Amorphous Phases" @default.
• W2319938861 cites W1966517710 @default.
• W2319938861 cites W1973036768 @default.
• W2319938861 cites W1973259166 @default.
• W2319938861 cites W1978169969 @default.
• W2319938861 cites W1981796897 @default.
• W2319938861 cites W1989871063 @default.
• W2319938861 cites W1996503148 @default.
• W2319938861 cites W1997096479 @default.
• W2319938861 cites W2002380603 @default.
• W2319938861 cites W2003955830 @default.
• W2319938861 cites W2019202976 @default.
• W2319938861 cites W2030280503 @default.
• W2319938861 cites W2031280181 @default.
• W2319938861 cites W2032246542 @default.
• W2319938861 cites W2032638339 @default.
• W2319938861 cites W2034078366 @default.
• W2319938861 cites W2034332162 @default.
• W2319938861 cites W2035535068 @default.
• W2319938861 cites W2042201510 @default.
• W2319938861 cites W2044671580 @default.
• W2319938861 cites W2053918101 @default.
• W2319938861 cites W2056014217 @default.
• W2319938861 cites W2076915379 @default.
• W2319938861 cites W2079480848 @default.
• W2319938861 cites W2080771304 @default.
• W2319938861 cites W2082242452 @default.
• W2319938861 cites W2083376344 @default.
• W2319938861 cites W2085114321 @default.
• W2319938861 cites W2085368583 @default.
• W2319938861 cites W2091279444 @default.
• W2319938861 cites W2091749430 @default.
• W2319938861 cites W2093907133 @default.
• W2319938861 cites W2141711694 @default.
• W2319938861 cites W2315722001 @default.
• W2319938861 cites W2323647180 @default.
• W2319938861 cites W2323841723 @default.
• W2319938861 cites W4242591046 @default.
• W2319938861 cites W620458739 @default.
• W2319938861 doi "https://doi.org/10.1021/jp307873m" @default.
• W2319938861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23030378" @default.
• W2319938861 hasPublicationYear "2012" @default.
• W2319938861 type Work @default.
• W2319938861 sameAs 2319938861 @default.
• W2319938861 citedByCount "9" @default.
• W2319938861 countsByYear W23199388612013 @default.
• W2319938861 countsByYear W23199388612014 @default.
• W2319938861 countsByYear W23199388612015 @default.
• W2319938861 countsByYear W23199388612016 @default.
• W2319938861 countsByYear W23199388612018 @default.
• W2319938861 countsByYear W23199388612023 @default.
• W2319938861 crossrefType "journal-article" @default.
• W2319938861 hasAuthorship W2319938861A5034089618 @default.
• W2319938861 hasAuthorship W2319938861A5067800648 @default.
• W2319938861 hasAuthorship W2319938861A5069492269 @default.
• W2319938861 hasAuthorship W2319938861A5087559023 @default.
• W2319938861 hasAuthorship W2319938861A5089840521 @default.
• W2319938861 hasConcept C112887158 @default.
• W2319938861 hasConcept C113196181 @default.
• W2319938861 hasConcept C120665830 @default.
• W2319938861 hasConcept C121332964 @default.
• W2319938861 hasConcept C160892712 @default.
• W2319938861 hasConcept C178790620 @default.
• W2319938861 hasConcept C185592680 @default.
• W2319938861 hasConcept C192468462 @default.
• W2319938861 hasConcept C192562407 @default.
• W2319938861 hasConcept C199360897 @default.
• W2319938861 hasConcept C203036418 @default.
• W2319938861 hasConcept C2781285689 @default.
• W2319938861 hasConcept C32891209 @default.
• W2319938861 hasConcept C32909587 @default.
• W2319938861 hasConcept C40003534 @default.
• W2319938861 hasConcept C41008148 @default.
• W2319938861 hasConcept C56052488 @default.
• W2319938861 hasConcept C62520636 @default.
• W2319938861 hasConcept C75473681 @default.
• W2319938861 hasConcept C8010536 @default.
• W2319938861 hasConcept C91881484 @default.
• W2319938861 hasConceptScore W2319938861C112887158 @default.
• W2319938861 hasConceptScore W2319938861C113196181 @default.
• W2319938861 hasConceptScore W2319938861C120665830 @default.
• W2319938861 hasConceptScore W2319938861C121332964 @default.
• W2319938861 hasConceptScore W2319938861C160892712 @default.
• W2319938861 hasConceptScore W2319938861C178790620 @default.
• W2319938861 hasConceptScore W2319938861C185592680 @default.
• W2319938861 hasConceptScore W2319938861C192468462 @default.
• W2319938861 hasConceptScore W2319938861C192562407 @default.
• W2319938861 hasConceptScore W2319938861C199360897 @default.
• W2319938861 hasConceptScore W2319938861C203036418 @default.

• next