Matches in SemOpenAlex for { <https://semopenalex.org/work/W2319963263> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2319963263 abstract "The corpus callosum connects cerebral hemispheres and is the largest axon tract in the mammalian brain. Callosal malformations are among the most common congenital brain anomalies and are associated with a wide range of neuropsychological deficits. Crossing of the midline by callosal axons relies on a proper midline environment that harbors guidepost cells emitting guidance cues to instruct callosal axon navigation. Little is known about what controls the formation of the midline environment. We find that two components of the Hippo pathway, the tumor suppressor Nf2 (Merlin) and the transcriptional coactivator Yap (Yap1), regulate guidepost development and expression of the guidance cue Slit2 in mouse. During normal brain development, Nf2 suppresses Yap activity in neural progenitor cells to promote guidepost cell differentiation and prevent ectopic Slit2 expression. Loss of Nf2 causes malformation of midline guideposts and Slit2 upregulation, resulting in callosal agenesis. Slit2 heterozygosity and Yap deletion both restore callosal formation in Nf2 mutants. Furthermore, selectively elevating Yap activity in midline neural progenitors is sufficient to disrupt guidepost formation, upregulate Slit2 and prevent midline crossing. The Hippo pathway is known for its role in controlling organ growth and tumorigenesis. Our study identifies a novel role of this pathway in axon guidance. Moreover, by linking axon pathfinding and neural progenitor behaviors, our results provide an example of the intricate coordination between growth and wiring during brain development." @default.
- W2319963263 created "2016-06-24" @default.
- W2319963263 creator A5030187435 @default.
- W2319963263 creator A5056156805 @default.
- W2319963263 creator A5064740384 @default.
- W2319963263 creator A5067458016 @default.
- W2319963263 date "2014-11-15" @default.
- W2319963263 modified "2023-09-27" @default.
- W2319963263 title "The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap" @default.
- W2319963263 cites W2147027546 @default.
- W2319963263 doi "https://doi.org/10.1242/jcs.164723" @default.
- W2319963263 hasPublicationYear "2014" @default.
- W2319963263 type Work @default.
- W2319963263 sameAs 2319963263 @default.
- W2319963263 citedByCount "0" @default.
- W2319963263 crossrefType "journal-article" @default.
- W2319963263 hasAuthorship W2319963263A5030187435 @default.
- W2319963263 hasAuthorship W2319963263A5056156805 @default.
- W2319963263 hasAuthorship W2319963263A5064740384 @default.
- W2319963263 hasAuthorship W2319963263A5067458016 @default.
- W2319963263 hasConcept C104317684 @default.
- W2319963263 hasConcept C105702510 @default.
- W2319963263 hasConcept C136834591 @default.
- W2319963263 hasConcept C169760540 @default.
- W2319963263 hasConcept C172512520 @default.
- W2319963263 hasConcept C200707615 @default.
- W2319963263 hasConcept C201750760 @default.
- W2319963263 hasConcept C2778183499 @default.
- W2319963263 hasConcept C2779530196 @default.
- W2319963263 hasConcept C28328180 @default.
- W2319963263 hasConcept C461258 @default.
- W2319963263 hasConcept C54355233 @default.
- W2319963263 hasConcept C62478195 @default.
- W2319963263 hasConcept C69125201 @default.
- W2319963263 hasConcept C78577261 @default.
- W2319963263 hasConcept C86803240 @default.
- W2319963263 hasConcept C95444343 @default.
- W2319963263 hasConceptScore W2319963263C104317684 @default.
- W2319963263 hasConceptScore W2319963263C105702510 @default.
- W2319963263 hasConceptScore W2319963263C136834591 @default.
- W2319963263 hasConceptScore W2319963263C169760540 @default.
- W2319963263 hasConceptScore W2319963263C172512520 @default.
- W2319963263 hasConceptScore W2319963263C200707615 @default.
- W2319963263 hasConceptScore W2319963263C201750760 @default.
- W2319963263 hasConceptScore W2319963263C2778183499 @default.
- W2319963263 hasConceptScore W2319963263C2779530196 @default.
- W2319963263 hasConceptScore W2319963263C28328180 @default.
- W2319963263 hasConceptScore W2319963263C461258 @default.
- W2319963263 hasConceptScore W2319963263C54355233 @default.
- W2319963263 hasConceptScore W2319963263C62478195 @default.
- W2319963263 hasConceptScore W2319963263C69125201 @default.
- W2319963263 hasConceptScore W2319963263C78577261 @default.
- W2319963263 hasConceptScore W2319963263C86803240 @default.
- W2319963263 hasConceptScore W2319963263C95444343 @default.
- W2319963263 hasLocation W23199632631 @default.
- W2319963263 hasOpenAccess W2319963263 @default.
- W2319963263 hasPrimaryLocation W23199632631 @default.
- W2319963263 hasRelatedWork W1547340514 @default.
- W2319963263 hasRelatedWork W175050938 @default.
- W2319963263 hasRelatedWork W2013369476 @default.
- W2319963263 hasRelatedWork W2042740677 @default.
- W2319963263 hasRelatedWork W2059986442 @default.
- W2319963263 hasRelatedWork W2063183827 @default.
- W2319963263 hasRelatedWork W2074225039 @default.
- W2319963263 hasRelatedWork W2076114668 @default.
- W2319963263 hasRelatedWork W2091754328 @default.
- W2319963263 hasRelatedWork W2147538622 @default.
- W2319963263 hasRelatedWork W2153998686 @default.
- W2319963263 hasRelatedWork W2158907386 @default.
- W2319963263 hasRelatedWork W2163455551 @default.
- W2319963263 hasRelatedWork W2284532304 @default.
- W2319963263 hasRelatedWork W2802905100 @default.
- W2319963263 hasRelatedWork W2803412456 @default.
- W2319963263 hasRelatedWork W2948625874 @default.
- W2319963263 hasRelatedWork W3072092048 @default.
- W2319963263 hasRelatedWork W3087181715 @default.
- W2319963263 hasRelatedWork W2106822889 @default.
- W2319963263 isParatext "false" @default.
- W2319963263 isRetracted "false" @default.
- W2319963263 magId "2319963263" @default.
- W2319963263 workType "article" @default.