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- W2320001394 abstract "Background The transcription factor forkhead box P3 (Foxp3) plays an essential role in the development and function of regulatory T cells. Aims To examine the effect of hyperlipidemia on the expression of Foxp3 in mice. Methods Twenty-four 8-week-old male apolipoprotein E (ApoE)−/− mice on a C57BL/6 background were randomly divided into control group and high fat diet group, 12 mice per group. The blood-lipid levels, the number of Foxp3+CD4+ CD25+ T cells, and the size of the atherosclerotic lesions in every group were measured. The expression levels of Foxp3 in different tissues were detected. Results Compared with the control group, the level of plasma lipids was significantly higher in the high fat-fed group, but the number and function of Foxp3+CD4+ CD25+ T cells, the levels of Foxp3 protein expression, and Foxp3 gene transcript in selected tissues were lower in the high fat-fed group. Conclusion Hyperlipidemia inhibits the expression and function of Foxp3 in various immune organs, which may be one of the mechanisms by which hyperlipidemia aggravates the formation of atherosclerosis." @default.
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- W2320001394 date "2014-04-01" @default.
- W2320001394 modified "2023-09-23" @default.
- W2320001394 title "Effect of hyperlipidemia on Foxp3 expression in apolipoprotein E-knockout mice" @default.
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- W2320001394 doi "https://doi.org/10.2459/jcm.0b013e3283641b9c" @default.
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