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- W2320003171 abstract "Current therapies in left ventricular systolic dysfunction and end-stage heart failure include mechanical assist devices or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option that overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability of the acellular ventricular extracellular matrix (AVEM) model. Acellular ventricular extracellular matrix was fabricated by culturing 4 million rat neonatal cardiac cells around an excised acellular ventricular segment. Acellular ventricular extracellular matrix generated a maximum spontaneous contractile force of 388.3 μN and demonstrated a Frank–Starling relationship at varying pretensions. Histologic assessment displayed cell cohesion and adhesion within the AVEM as a result of passive cell seeding. ASAIO Journal 2015; 61:61–70." @default.
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- W2320003171 date "2015-01-01" @default.
- W2320003171 modified "2023-09-26" @default.
- W2320003171 title "Engineering 3D Bio-Artificial Heart Muscle" @default.
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- W2320003171 doi "https://doi.org/10.1097/mat.0000000000000158" @default.
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