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- W2320008710 endingPage "63" @default.
- W2320008710 startingPage "52" @default.
- W2320008710 abstract "The high mortality rate associated with cancer and its resistance to conventional treatments such as radiation and chemotherapy has led to the investigation of a variety of anti-cancer immunotherapies. The development of novel immunotherapies has been bolstered by the discovery of tumor-associated antigens (TAAs), through gene sequencing and proteomics. One such immunotherapy employs established allogeneic human cancer cell lines to induce antitumor immunity in patients through TAA presentation. Allogeneic cancer immunotherapies are desirable in a clinical setting due to their ease of production and availability. This review aims to summarize clinical trials of allogeneic tumor immunotherapies in various cancer types. To date, clinical trials have shown limited success due potentially to extensive degrees of inter- and intra-tumoral heterogeneity found among cancer patients. However, these clinical results provide guidance for the rational design and creation of more effective allogeneic tumor immunotherapies for use as monotherapies or in combination with other therapies." @default.
- W2320008710 created "2016-06-24" @default.
- W2320008710 creator A5001782090 @default.
- W2320008710 creator A5009374630 @default.
- W2320008710 creator A5052762743 @default.
- W2320008710 creator A5061915588 @default.
- W2320008710 creator A5073494284 @default.
- W2320008710 creator A5076297695 @default.
- W2320008710 creator A5084517888 @default.
- W2320008710 date "2013-09-24" @default.
- W2320008710 modified "2023-10-14" @default.
- W2320008710 title "Allogeneic tumor cell vaccines" @default.
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