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• W2320009895 abstract "The distribution and excretion of 60CoCl2 administered subcutaneously or intraperitoneally into Ehrlich ascites cancer-bearing mice were examined with the following results.1. The concentration of 60Co in various organs of cancer-bearing mice was generally a compared with the control, especially in kidney and blood. The urinary and fecal excretion of 60Co in 24 hours had no differnce in control and experimental groups. The uptake of 60Co by ascites cancer cells was more compared with the other organs.2. In ascites cancer intraperitoneally implanted mice, the time course of the changes of 60Co distribution were examined. At 6 hours after the intraperitoneal injection, 60Co concentration in ascites cancer cells was highest, but later its concentration decreased gradually.3. At 1, 6, 12 and 24 hours after the intraperitoneal administration of 60Co, its distributionin subcellular fractions of Ehrlich ascites cancer cells was examined. Nuclear fraction had the highest concentration, followed by supernatant, microsomal and mitochondrial fractions in the descending order, and these concentrations did not relate to the lapse of hours after the 60Co administration.4. Concerning the effects of continual administration of anticancer agents to cancer bearing-mice, Mitomycin C and hydrocortisone acetate inhibited the ascites retention and corrected the disturbances of 60Co distribution observed in kidney and blood. Toyomycin inhibited the ascites retention without any effects on 60Co distribution. Nitromin, Tespamin and Merphyrin had no effects on grade of ascites retention and concentration of 60Co in several organs compared with the control.5. Soon after the intraperitoneal administration of 60Co to cancer intraperitoneally implanted mice, anticancer agents, amino acids, chelating agents and various salts were administered intraperitoneally and after 1 hour their effects on the distribution of 60Co were examined, On the effects of anticancer agents, Toyomycin inhibited 60Co uptake by cancer cells, but Nitromin increased it conversely, Mitomycin, Tespamin and Merphyrin did not affect 60Co uptake by cancer cells, In any cases the distribution of 60Co in other organs did not change compared with the control, On the effects of amino acids, Penicillamine, Cysteine and and Histidine inhibited 60Co uptake by cancer cells, but Glycine had no effect on it. In many cases 60Co concentration in the kidney was decreased, On the effects of chelating agents, EDTA, BAL and Na mercaptoacetate inhibited 60Co uptake by cancer cells, but dihydrothioctic acid increased it conversely, 60Co distributions in other organs were varied in case and case, On the effects of salts, Co2+, Mn2+, and Zn2+ inhibited 60Co uptake by cancer cells and increased 60Co retention in ascites supernatant, Mg2+, Fe2+, Ni2+ and Cu2+ did not affect both 60Co uptake in cancer cells and 60Co retention in ascites supernatant. 60Co distributions in other organs were varied in case and case and clear definite tendency did not observe in the 60Co distribution among the organs." @default.
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• W2320009895 date "1967-01-01" @default.
• W2320009895 modified "2023-09-27" @default.
• W2320009895 title "STUDIES ON THE DISTRIBUTION AND EXCRETION OF 59FE IN EHRLICH ASCITES CANCER BEARING-MICE" @default.
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• W2320009895 doi "https://doi.org/10.2974/kmj1951.17.437" @default.
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