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- W2320021683 abstract "Aims: Calcineurin inhibitors (CNIs) have nephrotoxic side effects. In heart transplant (HTx) recipients, CNI-free immunosuppressive therapy with Everolimus (EVL) and Mycophenolic-acid (MPA) derivatives seems to be a reliable treatment option for avoiding end-stage chronic kidney disease (CKD). Methods: Between January 2010 and October 2010 we switched 13 HTx recipients with CKD stages 3–4 from low-dose CNI plus EVL over to MPA plus EVL. Kidney function, blood cell counts and clinical outcome were evaluated during a 6-month follow-up period. Results: Three patients developed a herpes zoster-induced thoracic infection. One other patient developed pneumonia. The patient with pneumonia died of a septic shock 42 day after the introduction of MPA plus EVL. No cardiac rejection occurred. Mean creatinine levels decreased from 2.4mg/dl (range 1.7–2.5mg/dl) to 1.7mg/dl (range: 1.0–2.2mg/dl) (p0.001). Mean blood urea nitrogen decreased from 114mg/dl (range: 59–190mg/dl) to 80mg/dl (range:51–140mg/dl) (P=0.032). Blood cells counts remained stable. Conclusion: In HTx patients with CNI-induced CKD stages 3–4, the introduction of MPA plus EVL was associated with moderate beneficial effects on kidney function. However, our data do not exclude the possibility that CNI-free immunosuppressive therapy with MPA is a risk factor for the occurrence of infections." @default.
- W2320021683 created "2016-06-24" @default.
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- W2320021683 date "2012-01-18" @default.
- W2320021683 modified "2023-09-26" @default.
- W2320021683 title "Clinical outcome in heart transplant recipients with chronic kidney disease after introduction of calcineurin inhibitor free immunosuppressive therapy" @default.
- W2320021683 doi "https://doi.org/10.1055/s-0031-1297784" @default.
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