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- W2320039983 abstract "Sentinel lymph node biopsy (SLNB) was developed as a new modality in the surgical diagnosis of lymph node metastases. Dyes and radioisotopes are the major tracers for the detection of sentinel lymph nodes (SLN). However, dyes tend to infiltrate excessively into the interstitium due to their small molecular size (less than several nanometers), resulting in difficulties in maintaining a clear surgical field, whereas radioisotopes are available only in a limited number of hospitals. Fluorescent nanoparticles are suitable candidates as SLN tracers in solving these problems, because we can choose a suitable particle size and near-infrared fluorescence wavelengths. However, the use of nanoparticles involves safety issues and many attempts have been made to produce insulating coats to obviate these issues. In addition, the preparation of a uniform insulating layer is important to decrease quality variations in an SLN tracer. We succeeded in coating fluorescent polystyrene nanoparticles of 40-nm size with a uniform silica layer of 13-nm thickness by the modified Stober method. The popliteal lymph node could be visualized using silica-coated nanoparticles injected into the rat foot. The application of silica-coated fluorescent nanoparticles was demonstrated for SLN mapping in an animal model. Together, the chemical, optical, and in vivo data presented in this study demonstrate the potential role of silica-coated fluorescent nanoparticles for imaging in medical treatments." @default.
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- W2320039983 date "2012-02-01" @default.
- W2320039983 modified "2023-10-17" @default.
- W2320039983 title "SILICA COATING OF FLUORESCENT NANOPARTICLES PROLONGS ENHANCEMENT OF SENTINEL LYMPH NODES" @default.
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- W2320039983 doi "https://doi.org/10.1142/9781848169067_0068" @default.
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