Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320041514> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2320041514 endingPage "1400" @default.
- W2320041514 startingPage "1392" @default.
- W2320041514 abstract "The purpose of this study was to investigate the effect of concomitant use on important clinical outcomes.In this retrospective cohort study, a cohort of new metformin users was identified between 2004 and 2010 and followed up until termination of insurance coverage, December 31, 2010, or the outcomes were reached. The primary outcome was a composite of time to all-cause mortality or hospitalization; our secondary outcome was time to cardiovascular hospitalization. Exposures to metformin, a proton pump inhibitor (PPI), and/or a histamine2 receptor antagonist (H2RA) were compared with a Cox proportional hazards model after adjustment.Relative to metformin-only users, metformin and PPI users were at increased risk of the primary outcome (adjusted hazard ratio [HR] = 1.55; 95% CI, 1.46-1.64); metformin and H2RA users also had an elevated risk (adjusted HR = 1.29; 95% CI, 0.97-1.70). Similar patterns were seen with cardiovascular-specific hospitalization. Compared with no drug use, metformin users had an increased risk of the primary outcome, but risk was substantially elevated when patients were taking PPIs or H2RAs, alone or in combination with metformin.Concomitant use of metformin and a PPI or metformin and an H2RA were associated with an increased risk of death or hospitalization. This finding suggests that the harm observed may not be due to a specific drug interaction but uncontrolled confounding secondary to an increased risk in those patients using a PPI or H2RA." @default.
- W2320041514 created "2016-06-24" @default.
- W2320041514 creator A5022506087 @default.
- W2320041514 creator A5067514299 @default.
- W2320041514 creator A5067717687 @default.
- W2320041514 creator A5086604663 @default.
- W2320041514 date "2016-06-01" @default.
- W2320041514 modified "2023-09-23" @default.
- W2320041514 title "Safety of Concomitant Metformin and Proton Pump Inhibitor Use: A Population Retrospective Cohort Study" @default.
- W2320041514 cites W1901059681 @default.
- W2320041514 cites W1966367806 @default.
- W2320041514 cites W2004984116 @default.
- W2320041514 cites W2016355724 @default.
- W2320041514 cites W2017281521 @default.
- W2320041514 cites W2020045524 @default.
- W2320041514 cites W2031697192 @default.
- W2320041514 cites W2033414137 @default.
- W2320041514 cites W2049182490 @default.
- W2320041514 cites W2061582714 @default.
- W2320041514 cites W2071521423 @default.
- W2320041514 cites W2081768449 @default.
- W2320041514 cites W2130216325 @default.
- W2320041514 cites W2140345185 @default.
- W2320041514 cites W2150489334 @default.
- W2320041514 cites W2162180419 @default.
- W2320041514 doi "https://doi.org/10.1016/j.clinthera.2016.03.024" @default.
- W2320041514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27061884" @default.
- W2320041514 hasPublicationYear "2016" @default.
- W2320041514 type Work @default.
- W2320041514 sameAs 2320041514 @default.
- W2320041514 citedByCount "6" @default.
- W2320041514 countsByYear W23200415142017 @default.
- W2320041514 countsByYear W23200415142018 @default.
- W2320041514 countsByYear W23200415142019 @default.
- W2320041514 countsByYear W23200415142022 @default.
- W2320041514 crossrefType "journal-article" @default.
- W2320041514 hasAuthorship W2320041514A5022506087 @default.
- W2320041514 hasAuthorship W2320041514A5067514299 @default.
- W2320041514 hasAuthorship W2320041514A5067717687 @default.
- W2320041514 hasAuthorship W2320041514A5086604663 @default.
- W2320041514 hasConcept C126322002 @default.
- W2320041514 hasConcept C167135981 @default.
- W2320041514 hasConcept C201903717 @default.
- W2320041514 hasConcept C207103383 @default.
- W2320041514 hasConcept C2779306644 @default.
- W2320041514 hasConcept C2779384505 @default.
- W2320041514 hasConcept C2780323712 @default.
- W2320041514 hasConcept C2781025758 @default.
- W2320041514 hasConcept C44249647 @default.
- W2320041514 hasConcept C50382708 @default.
- W2320041514 hasConcept C71924100 @default.
- W2320041514 hasConcept C72563966 @default.
- W2320041514 hasConcept C77350462 @default.
- W2320041514 hasConceptScore W2320041514C126322002 @default.
- W2320041514 hasConceptScore W2320041514C167135981 @default.
- W2320041514 hasConceptScore W2320041514C201903717 @default.
- W2320041514 hasConceptScore W2320041514C207103383 @default.
- W2320041514 hasConceptScore W2320041514C2779306644 @default.
- W2320041514 hasConceptScore W2320041514C2779384505 @default.
- W2320041514 hasConceptScore W2320041514C2780323712 @default.
- W2320041514 hasConceptScore W2320041514C2781025758 @default.
- W2320041514 hasConceptScore W2320041514C44249647 @default.
- W2320041514 hasConceptScore W2320041514C50382708 @default.
- W2320041514 hasConceptScore W2320041514C71924100 @default.
- W2320041514 hasConceptScore W2320041514C72563966 @default.
- W2320041514 hasConceptScore W2320041514C77350462 @default.
- W2320041514 hasIssue "6" @default.
- W2320041514 hasLocation W23200415141 @default.
- W2320041514 hasLocation W23200415142 @default.
- W2320041514 hasOpenAccess W2320041514 @default.
- W2320041514 hasPrimaryLocation W23200415141 @default.
- W2320041514 hasRelatedWork W1969969925 @default.
- W2320041514 hasRelatedWork W2218363463 @default.
- W2320041514 hasRelatedWork W2511583075 @default.
- W2320041514 hasRelatedWork W2809909380 @default.
- W2320041514 hasRelatedWork W2978227646 @default.
- W2320041514 hasRelatedWork W3010794336 @default.
- W2320041514 hasRelatedWork W4283724815 @default.
- W2320041514 hasRelatedWork W4284894593 @default.
- W2320041514 hasRelatedWork W4322719317 @default.
- W2320041514 hasRelatedWork W4366529679 @default.
- W2320041514 hasVolume "38" @default.
- W2320041514 isParatext "false" @default.
- W2320041514 isRetracted "false" @default.
- W2320041514 magId "2320041514" @default.
- W2320041514 workType "article" @default.